Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

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Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clost...

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Bibliographic Details
Main Authors:	van Eijk, Erika, Paschalis, Vasileios, Green, Matthew, Friggen, Annemieke H., Larson, Marilynn A., Spriggs, Keith, Briggs, Geoffrey S., Soultanas, Panos, Smits, Wiep Klaas
Format:	Article
Language:	English
Published:	Royal Society Publishing 2016
Subjects:	DNA replication initiation helicase loading and activation primase trinucleotide specificity ATPase Clostridium difficile
Online Access:	https://eprints.nottingham.ac.uk/44719/

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