DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

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DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

Hel308 helicases promote genome stability linked to DNA replication in archaea, and have homologues in metazoans. In the crystal structure of archaeal Hel308 bound to a tailed DNA duplex, core helicase domains encircle single-stranded DNA (ssDNA) in a “ratchet” for directional translocation. A winge...

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Bibliographic Details
Main Authors:	Northall, Sarah J., Buckley, Ryan, Jones, Nathan, Penedo, J. Carlos, Soultanas, Panos, Bolt, Edward L.
Format:	Article
Published:	Elsevier 2017
Subjects:	Helicase; DNA Repair; Homologous Recombination; Archaea; HelQ
Online Access:	https://eprints.nottingham.ac.uk/44718/

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