Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells
Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by numbe...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Impact Journals
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44621/ |
| _version_ | 1848796959245074432 |
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| author | Gomzikova, Marina Zhuravleva, Margarita Miftakhova, Regina Arkhipova, Svetlana Evtugin, Vladimir Khaiboullina, Sventlana Kiyasov, Andrey Persson, Jenny Mongan, Nigel P. Pestell, Richard Rizvanov, Albert A. |
| author_facet | Gomzikova, Marina Zhuravleva, Margarita Miftakhova, Regina Arkhipova, Svetlana Evtugin, Vladimir Khaiboullina, Sventlana Kiyasov, Andrey Persson, Jenny Mongan, Nigel P. Pestell, Richard Rizvanov, Albert A. |
| author_sort | Gomzikova, Marina |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo. |
| first_indexed | 2025-11-14T19:56:16Z |
| format | Article |
| id | nottingham-44621 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:56:16Z |
| publishDate | 2017 |
| publisher | Impact Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-446212020-05-04T18:57:42Z https://eprints.nottingham.ac.uk/44621/ Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells Gomzikova, Marina Zhuravleva, Margarita Miftakhova, Regina Arkhipova, Svetlana Evtugin, Vladimir Khaiboullina, Sventlana Kiyasov, Andrey Persson, Jenny Mongan, Nigel P. Pestell, Richard Rizvanov, Albert A. Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis in vitro and in vivo. Impact Journals 2017-07-31 Article PeerReviewed Gomzikova, Marina, Zhuravleva, Margarita, Miftakhova, Regina, Arkhipova, Svetlana, Evtugin, Vladimir, Khaiboullina, Sventlana, Kiyasov, Andrey, Persson, Jenny, Mongan, Nigel P., Pestell, Richard and Rizvanov, Albert A. (2017) Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells. Oncotarget, 8 (41). pp. 70496-70507. ISSN 1949-2553 extracellular vesicles membrane vesicles Cytochalasin B-induced membrane vesicles angiogenesis cell-free therapy http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19723&path[]=63002 doi:10.18632/oncotarget.19723 doi:10.18632/oncotarget.19723 |
| spellingShingle | extracellular vesicles membrane vesicles Cytochalasin B-induced membrane vesicles angiogenesis cell-free therapy Gomzikova, Marina Zhuravleva, Margarita Miftakhova, Regina Arkhipova, Svetlana Evtugin, Vladimir Khaiboullina, Sventlana Kiyasov, Andrey Persson, Jenny Mongan, Nigel P. Pestell, Richard Rizvanov, Albert A. Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title | Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title_full | Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title_fullStr | Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title_full_unstemmed | Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title_short | Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells |
| title_sort | cytochalasin b-induced membrane vesicles convey angiogenic activity of parental cells |
| topic | extracellular vesicles membrane vesicles Cytochalasin B-induced membrane vesicles angiogenesis cell-free therapy |
| url | https://eprints.nottingham.ac.uk/44621/ https://eprints.nottingham.ac.uk/44621/ https://eprints.nottingham.ac.uk/44621/ |