Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression
Background Age-related loss of functional muscle mass is associated with reduced functional ability and life expectancy. In disseminated cancer, age-related muscle loss may be exacerbated by cachexia and poor nutritional intake, increasing functional decline, morbidity and accelerate death. Patie...
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| Format: | Article |
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Springer Verlag
2015
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| Online Access: | https://eprints.nottingham.ac.uk/44551/ |
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| author | Gakhar, H. Dhillon, Amandeep Kaur Blackwell, J. Hussain, K. Bommireddy, R. Klezl, Z. Williams, John P. |
| author_facet | Gakhar, H. Dhillon, Amandeep Kaur Blackwell, J. Hussain, K. Bommireddy, R. Klezl, Z. Williams, John P. |
| author_sort | Gakhar, H. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Age-related loss of functional muscle mass is associated with reduced functional ability and life expectancy. In disseminated cancer, age-related muscle loss may be exacerbated by cachexia and poor nutritional intake, increasing functional decline, morbidity and accelerate death. Patients with spinal metastases frequently present for decompressive surgery with decision to operate based upon functional assessment. A subjective assessment of physical performance has, however, been shown to be a poor indicator of life expectancy in these patients. We aimed to develop an objective measure based upon lean muscle mass to aid decision making, in these individuals, by investigating the association between muscle mass and 1-year survival.
Methods
Muscle mass was calculated as total psoas area (TPA)/ vertebral body area (VBA), by two independent blinded doctors from CT images, acquired within 7 days of spinal metastases surgery, at the mid L3 vertebral level. Outcome at 1 year following surgery was recorded from a prospectively updated metastatic spinal cord compression database.
Results
86 patients were followed for 1 year, with an overall mortality of 39.5 %. Mortality rates at 1 year were significantly high among patients in the lowest quartile of muscle mass, compared with those in the highest quartile (57.1 vs 23.8 %, p = 0.02).
Conclusion
Death within 1 year in individuals with spinal metastases is related to lean muscle mass at presentation. Assessment of lean muscle mass may inform decision to operate in patients with spinal metastases. |
| first_indexed | 2025-11-14T19:56:00Z |
| format | Article |
| id | nottingham-44551 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:56:00Z |
| publishDate | 2015 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-445512020-05-04T20:06:54Z https://eprints.nottingham.ac.uk/44551/ Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression Gakhar, H. Dhillon, Amandeep Kaur Blackwell, J. Hussain, K. Bommireddy, R. Klezl, Z. Williams, John P. Background Age-related loss of functional muscle mass is associated with reduced functional ability and life expectancy. In disseminated cancer, age-related muscle loss may be exacerbated by cachexia and poor nutritional intake, increasing functional decline, morbidity and accelerate death. Patients with spinal metastases frequently present for decompressive surgery with decision to operate based upon functional assessment. A subjective assessment of physical performance has, however, been shown to be a poor indicator of life expectancy in these patients. We aimed to develop an objective measure based upon lean muscle mass to aid decision making, in these individuals, by investigating the association between muscle mass and 1-year survival. Methods Muscle mass was calculated as total psoas area (TPA)/ vertebral body area (VBA), by two independent blinded doctors from CT images, acquired within 7 days of spinal metastases surgery, at the mid L3 vertebral level. Outcome at 1 year following surgery was recorded from a prospectively updated metastatic spinal cord compression database. Results 86 patients were followed for 1 year, with an overall mortality of 39.5 %. Mortality rates at 1 year were significantly high among patients in the lowest quartile of muscle mass, compared with those in the highest quartile (57.1 vs 23.8 %, p = 0.02). Conclusion Death within 1 year in individuals with spinal metastases is related to lean muscle mass at presentation. Assessment of lean muscle mass may inform decision to operate in patients with spinal metastases. Springer Verlag 2015-10 Article PeerReviewed Gakhar, H., Dhillon, Amandeep Kaur, Blackwell, J., Hussain, K., Bommireddy, R., Klezl, Z. and Williams, John P. (2015) Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression. European Spine Journal, 24 (10). pp. 2150-2155. ISSN 1432-0932 Metastatic spinal cord compression; Sarcopenia; Lean muscle mass https://link.springer.com/article/10.1007%2Fs00586-015-4050-7 doi:10.1007/s00586-015-4050-7 doi:10.1007/s00586-015-4050-7 |
| spellingShingle | Metastatic spinal cord compression; Sarcopenia; Lean muscle mass Gakhar, H. Dhillon, Amandeep Kaur Blackwell, J. Hussain, K. Bommireddy, R. Klezl, Z. Williams, John P. Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title | Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title_full | Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title_fullStr | Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title_full_unstemmed | Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title_short | Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| title_sort | study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression |
| topic | Metastatic spinal cord compression; Sarcopenia; Lean muscle mass |
| url | https://eprints.nottingham.ac.uk/44551/ https://eprints.nottingham.ac.uk/44551/ https://eprints.nottingham.ac.uk/44551/ |