Neural correlates of three types of negative life events during angry face processing in adolescents
Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal–limbic emotional regions. Participants (N = 685) w...
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| Format: | Article |
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Oxford
2016
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| Online Access: | https://eprints.nottingham.ac.uk/44534/ |
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| author | Gollier-Briant, Fanny Pallière-Martinot, Marie-Laure Lemaitre, Hervé Miranda, Ruben Vulser, Hélène Goodman, Robert Penttilä, Jani Struve, Maren Fadai, Tahmine Kappel, Viola Poustka, Luise Grimmer, Yvonne Bromberg, Uli Conrod, Patricia Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Büchel, Christian Flor, Herta Gallinat, Jürgen Garavan, Hugh Heinz, Andreas Lawrence, Claire Mann, Karl Nees, Frauke Paus, Tomas Pausova, Zdenka Frouin, Vincent Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Schumann, Gunter Martinot, Jean-Luc Artiges, Eric |
| author_facet | Gollier-Briant, Fanny Pallière-Martinot, Marie-Laure Lemaitre, Hervé Miranda, Ruben Vulser, Hélène Goodman, Robert Penttilä, Jani Struve, Maren Fadai, Tahmine Kappel, Viola Poustka, Luise Grimmer, Yvonne Bromberg, Uli Conrod, Patricia Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Büchel, Christian Flor, Herta Gallinat, Jürgen Garavan, Hugh Heinz, Andreas Lawrence, Claire Mann, Karl Nees, Frauke Paus, Tomas Pausova, Zdenka Frouin, Vincent Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Schumann, Gunter Martinot, Jean-Luc Artiges, Eric |
| author_sort | Gollier-Briant, Fanny |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal–limbic emotional regions. Participants (N = 685) were drawn from the Imagen database of 14-year-old community adolescents recruited in schools. They underwent functional MRI while viewing angry and neutral faces, as a probe to neural response to social threat. Lifetime NLEs were assessed using the ‘distress’, ‘family’ and ‘accident’ subscales from a life event dimensional questionnaire. Relationships between NLE subscale scores and neural response were investigated. Links of NLE subscales scores with anxiety or depression outcomes at the age of 16 years were also investigated. Lifetime ‘distress’ positively correlated with ventral-lateral orbitofrontal and temporal cortex activations during angry face processing. ‘Distress’ scores correlated with the probabilities of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder at the age of 16 years. Lifetime ‘family’ and ‘accident’ scores did not relate with neural response or follow-up conditions, however. Thus, different types of NLEs differentially predicted neural responses to threat during adolescence, and differentially predicted a de novo internalizing condition 2 years later. The deleterious effect of self-referential NLEs is suggested. |
| first_indexed | 2025-11-14T19:55:56Z |
| format | Article |
| id | nottingham-44534 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:56Z |
| publishDate | 2016 |
| publisher | Oxford |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-445342020-05-04T19:59:42Z https://eprints.nottingham.ac.uk/44534/ Neural correlates of three types of negative life events during angry face processing in adolescents Gollier-Briant, Fanny Pallière-Martinot, Marie-Laure Lemaitre, Hervé Miranda, Ruben Vulser, Hélène Goodman, Robert Penttilä, Jani Struve, Maren Fadai, Tahmine Kappel, Viola Poustka, Luise Grimmer, Yvonne Bromberg, Uli Conrod, Patricia Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Büchel, Christian Flor, Herta Gallinat, Jürgen Garavan, Hugh Heinz, Andreas Lawrence, Claire Mann, Karl Nees, Frauke Paus, Tomas Pausova, Zdenka Frouin, Vincent Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Schumann, Gunter Martinot, Jean-Luc Artiges, Eric Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal–limbic emotional regions. Participants (N = 685) were drawn from the Imagen database of 14-year-old community adolescents recruited in schools. They underwent functional MRI while viewing angry and neutral faces, as a probe to neural response to social threat. Lifetime NLEs were assessed using the ‘distress’, ‘family’ and ‘accident’ subscales from a life event dimensional questionnaire. Relationships between NLE subscale scores and neural response were investigated. Links of NLE subscales scores with anxiety or depression outcomes at the age of 16 years were also investigated. Lifetime ‘distress’ positively correlated with ventral-lateral orbitofrontal and temporal cortex activations during angry face processing. ‘Distress’ scores correlated with the probabilities of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder at the age of 16 years. Lifetime ‘family’ and ‘accident’ scores did not relate with neural response or follow-up conditions, however. Thus, different types of NLEs differentially predicted neural responses to threat during adolescence, and differentially predicted a de novo internalizing condition 2 years later. The deleterious effect of self-referential NLEs is suggested. Oxford 2016-12 Article PeerReviewed Gollier-Briant, Fanny, Pallière-Martinot, Marie-Laure, Lemaitre, Hervé, Miranda, Ruben, Vulser, Hélène, Goodman, Robert, Penttilä, Jani, Struve, Maren, Fadai, Tahmine, Kappel, Viola, Poustka, Luise, Grimmer, Yvonne, Bromberg, Uli, Conrod, Patricia, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Büchel, Christian, Flor, Herta, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Lawrence, Claire, Mann, Karl, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Frouin, Vincent, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Schumann, Gunter, Martinot, Jean-Luc and Artiges, Eric (2016) Neural correlates of three types of negative life events during angry face processing in adolescents. Social Cognitive and Affective Neuroscience, 11 (12). pp. 1961-1969. ISSN 1749-5024 adolescence anxiety depression fMRI negative life events social threat https://academic.oup.com/scan/article/11/12/1961/2544445/Neural-correlates-of-three-types-of-negative-life doi:10.1093/scan/nsw100 doi:10.1093/scan/nsw100 |
| spellingShingle | adolescence anxiety depression fMRI negative life events social threat Gollier-Briant, Fanny Pallière-Martinot, Marie-Laure Lemaitre, Hervé Miranda, Ruben Vulser, Hélène Goodman, Robert Penttilä, Jani Struve, Maren Fadai, Tahmine Kappel, Viola Poustka, Luise Grimmer, Yvonne Bromberg, Uli Conrod, Patricia Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Büchel, Christian Flor, Herta Gallinat, Jürgen Garavan, Hugh Heinz, Andreas Lawrence, Claire Mann, Karl Nees, Frauke Paus, Tomas Pausova, Zdenka Frouin, Vincent Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Schumann, Gunter Martinot, Jean-Luc Artiges, Eric Neural correlates of three types of negative life events during angry face processing in adolescents |
| title | Neural correlates of three types of negative life events during angry face processing in adolescents |
| title_full | Neural correlates of three types of negative life events during angry face processing in adolescents |
| title_fullStr | Neural correlates of three types of negative life events during angry face processing in adolescents |
| title_full_unstemmed | Neural correlates of three types of negative life events during angry face processing in adolescents |
| title_short | Neural correlates of three types of negative life events during angry face processing in adolescents |
| title_sort | neural correlates of three types of negative life events during angry face processing in adolescents |
| topic | adolescence anxiety depression fMRI negative life events social threat |
| url | https://eprints.nottingham.ac.uk/44534/ https://eprints.nottingham.ac.uk/44534/ https://eprints.nottingham.ac.uk/44534/ |