Gene × environment interactions in schizophrenia: evidence from genetic mouse models
The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Hindawi
2016
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| Online Access: | https://eprints.nottingham.ac.uk/44495/ |
| _version_ | 1848796929310326784 |
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| author | Moran, Paula M. Stokes, Jennifer Marr, Julia Bock, Gavin Desbonnet, Lieve Waddington, J.L. O'Tuathaigh, C.M.P. |
| author_facet | Moran, Paula M. Stokes, Jennifer Marr, Julia Bock, Gavin Desbonnet, Lieve Waddington, J.L. O'Tuathaigh, C.M.P. |
| author_sort | Moran, Paula M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia. |
| first_indexed | 2025-11-14T19:55:47Z |
| format | Article |
| id | nottingham-44495 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:47Z |
| publishDate | 2016 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-444952020-05-04T18:05:11Z https://eprints.nottingham.ac.uk/44495/ Gene × environment interactions in schizophrenia: evidence from genetic mouse models Moran, Paula M. Stokes, Jennifer Marr, Julia Bock, Gavin Desbonnet, Lieve Waddington, J.L. O'Tuathaigh, C.M.P. The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia. Hindawi 2016-08-31 Article PeerReviewed Moran, Paula M., Stokes, Jennifer, Marr, Julia, Bock, Gavin, Desbonnet, Lieve, Waddington, J.L. and O'Tuathaigh, C.M.P. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016 . 2173748/1- 2173748/23. ISSN 1687-5443 https://www.hindawi.com/journals/np/2016/2173748/ doi:10.1155/2016/2173748 doi:10.1155/2016/2173748 |
| spellingShingle | Moran, Paula M. Stokes, Jennifer Marr, Julia Bock, Gavin Desbonnet, Lieve Waddington, J.L. O'Tuathaigh, C.M.P. Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title | Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title_full | Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title_fullStr | Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title_full_unstemmed | Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title_short | Gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| title_sort | gene × environment interactions in schizophrenia: evidence from genetic mouse models |
| url | https://eprints.nottingham.ac.uk/44495/ https://eprints.nottingham.ac.uk/44495/ https://eprints.nottingham.ac.uk/44495/ |