Scene-selective coding by single neurons in the human parahippocampal cortex
Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of s...
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| Format: | Article |
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National Academy of Sciences
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44486/ |
| _version_ | 1848796926646943744 |
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| author | Mormann, Florian Kornblith, Simon Cerf, Moran Ison, Matias J. Kraskov, Alexander Tran, Michelle Knieling, Simeon Quian Quiroga, Rodrigo Koch, Christof Fried, Itzhak |
| author_facet | Mormann, Florian Kornblith, Simon Cerf, Moran Ison, Matias J. Kraskov, Alexander Tran, Michelle Knieling, Simeon Quian Quiroga, Rodrigo Koch, Christof Fried, Itzhak |
| author_sort | Mormann, Florian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of scene-selective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area. |
| first_indexed | 2025-11-14T19:55:45Z |
| format | Article |
| id | nottingham-44486 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:45Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-444862020-05-04T18:29:03Z https://eprints.nottingham.ac.uk/44486/ Scene-selective coding by single neurons in the human parahippocampal cortex Mormann, Florian Kornblith, Simon Cerf, Moran Ison, Matias J. Kraskov, Alexander Tran, Michelle Knieling, Simeon Quian Quiroga, Rodrigo Koch, Christof Fried, Itzhak Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of scene-selective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area. National Academy of Sciences 2017-01-31 Article PeerReviewed Mormann, Florian, Kornblith, Simon, Cerf, Moran, Ison, Matias J., Kraskov, Alexander, Tran, Michelle, Knieling, Simeon, Quian Quiroga, Rodrigo, Koch, Christof and Fried, Itzhak (2017) Scene-selective coding by single neurons in the human parahippocampal cortex. Proceedings of the National Academy of Sciences, 114 (5). pp. 1153-1158. ISSN 1091-6490 Electrophysiology Single units Scene selectivity Population code https://doi.org/10.1073/pnas.1608159113 doi:10.1073/pnas.1608159113 doi:10.1073/pnas.1608159113 |
| spellingShingle | Electrophysiology Single units Scene selectivity Population code Mormann, Florian Kornblith, Simon Cerf, Moran Ison, Matias J. Kraskov, Alexander Tran, Michelle Knieling, Simeon Quian Quiroga, Rodrigo Koch, Christof Fried, Itzhak Scene-selective coding by single neurons in the human parahippocampal cortex |
| title | Scene-selective coding by single neurons in the human parahippocampal cortex |
| title_full | Scene-selective coding by single neurons in the human parahippocampal cortex |
| title_fullStr | Scene-selective coding by single neurons in the human parahippocampal cortex |
| title_full_unstemmed | Scene-selective coding by single neurons in the human parahippocampal cortex |
| title_short | Scene-selective coding by single neurons in the human parahippocampal cortex |
| title_sort | scene-selective coding by single neurons in the human parahippocampal cortex |
| topic | Electrophysiology Single units Scene selectivity Population code |
| url | https://eprints.nottingham.ac.uk/44486/ https://eprints.nottingham.ac.uk/44486/ https://eprints.nottingham.ac.uk/44486/ |