A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine
Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biop...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44427/ |
| _version_ | 1848796915004604416 |
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| author | Drinkall, Emma Wass, Matthew J. Coffey, Tracey J. Flynn, Robin J. |
| author_facet | Drinkall, Emma Wass, Matthew J. Coffey, Tracey J. Flynn, Robin J. |
| author_sort | Drinkall, Emma |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage. |
| first_indexed | 2025-11-14T19:55:34Z |
| format | Article |
| id | nottingham-44427 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:34Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-444272020-05-04T18:56:33Z https://eprints.nottingham.ac.uk/44427/ A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine Drinkall, Emma Wass, Matthew J. Coffey, Tracey J. Flynn, Robin J. Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9 h post-infection, with no effect of infection on IL-1β; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage. Elsevier 2017-07-23 Article PeerReviewed Drinkall, Emma, Wass, Matthew J., Coffey, Tracey J. and Flynn, Robin J. (2017) A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine. Veterinary Immunology and Immunopathology, 191 . pp. 1-4. ISSN 1873-2534 Cryptosporidium parvum; Biopsy; IL-17A; Intestine; Villi; Bovine http://www.sciencedirect.com/science/article/pii/S0165242717302945 doi:10.1016/j.vetimm.2017.07.009 doi:10.1016/j.vetimm.2017.07.009 |
| spellingShingle | Cryptosporidium parvum; Biopsy; IL-17A; Intestine; Villi; Bovine Drinkall, Emma Wass, Matthew J. Coffey, Tracey J. Flynn, Robin J. A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine |
| title | A rapid IL-17 response to Cryptosporidium parvum in
the bovine intestine |
| title_full | A rapid IL-17 response to Cryptosporidium parvum in
the bovine intestine |
| title_fullStr | A rapid IL-17 response to Cryptosporidium parvum in
the bovine intestine |
| title_full_unstemmed | A rapid IL-17 response to Cryptosporidium parvum in
the bovine intestine |
| title_short | A rapid IL-17 response to Cryptosporidium parvum in
the bovine intestine |
| title_sort | rapid il-17 response to cryptosporidium parvum in
the bovine intestine |
| topic | Cryptosporidium parvum; Biopsy; IL-17A; Intestine; Villi; Bovine |
| url | https://eprints.nottingham.ac.uk/44427/ https://eprints.nottingham.ac.uk/44427/ https://eprints.nottingham.ac.uk/44427/ |