Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability

Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability

Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides show only modest reactivity with oxidants. In the current study, we report kinetic data indicating that sele...

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Bibliographic Details
Main Authors: Karimi, Maryam, Ignasiak, Marta T., Chan, Bun, Croft, Anna K., Radom, Leo, Schiesser, Carl H., Pattison, David I., Davies, Michael J.
Format: Article
Published: Nature Publishing Group 2016
Online Access:https://eprints.nottingham.ac.uk/44425/

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