Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating
Catheter associated urinary tract infections (CA-UTIs) are the most common health related infections world wide, contributing significantly to patient morbidity and mortality and increased health care costs. To reduce the incidence of these infections, new materials that resist bacterial biofilm for...
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| Format: | Article |
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American Vacuum Society
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44396/ |
| _version_ | 1848796907542937600 |
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| author | Tyler, Bonnie J. Hook, Andrew L. Pelster, Andreas Williams, Paul Alexander, Morgan R. Arlinghaus, Heinrich F. |
| author_facet | Tyler, Bonnie J. Hook, Andrew L. Pelster, Andreas Williams, Paul Alexander, Morgan R. Arlinghaus, Heinrich F. |
| author_sort | Tyler, Bonnie J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Catheter associated urinary tract infections (CA-UTIs) are the most common health related infections world wide, contributing significantly to patient morbidity and mortality and increased health care costs. To reduce the incidence of these infections, new materials that resist bacterial biofilm formation are needed. A composite catheter material, consisting of bulk PDMS coated with a novel bacterial biofilm resistant polyacrylate (EGDPEA–co-DEGMA) has been proposed. The coated material shows excellent bacterial resistance when compared to commercial catheter materials but delamination of the coatings under mechanical stress presents a challenge. In this work, the use of oxygen plasma treatment to improve the wettability and reactivity of the PDMS catheter material and improve adhesion with the EGDPEA–co-DEGMA coating has been investigated. Argon Cluster 3D-imaging Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has been used to probe the buried adhesive interface between the EGDPEA–co-DEGMA coating and the treated PDMS. ToF-SIMS analysis was performed in both dry and frozen-hydrated states and results were compared to mechanical tests. From the ToF-SIMS data we have been able to observe the presence of PDMS, silicates, salt particles, cracks and water at the adhesive interface. In the dry catheters, low molecular weight PDMS oligomers at the interface were associated with poor adhesion. When hydrated, the hydrophilic silicates attracted water to the interface and led to easy delamination of the coating. The best adhesion results, under hydrated conditions, were obtained using a combination of 5 min O2 plasma treatment and silane primers. Cryo-ToF-SIMS analysis of the hydrated catheter material showed that the bond between the primed PDMS catheter and the EGDPEA–co-DEGMA coating was stable in the presence of water. The resulting catheter material was resisted Escherichia coli and Proteus mirabilis biofilm colonization by up to 95 % compared with uncoated PDMS after 10 days of continuous bacterial exposure and had the mechanical properties necessary for use as a urinary catheter. |
| first_indexed | 2025-11-14T19:55:26Z |
| format | Article |
| id | nottingham-44396 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:26Z |
| publishDate | 2017 |
| publisher | American Vacuum Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-443962020-05-04T18:45:13Z https://eprints.nottingham.ac.uk/44396/ Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating Tyler, Bonnie J. Hook, Andrew L. Pelster, Andreas Williams, Paul Alexander, Morgan R. Arlinghaus, Heinrich F. Catheter associated urinary tract infections (CA-UTIs) are the most common health related infections world wide, contributing significantly to patient morbidity and mortality and increased health care costs. To reduce the incidence of these infections, new materials that resist bacterial biofilm formation are needed. A composite catheter material, consisting of bulk PDMS coated with a novel bacterial biofilm resistant polyacrylate (EGDPEA–co-DEGMA) has been proposed. The coated material shows excellent bacterial resistance when compared to commercial catheter materials but delamination of the coatings under mechanical stress presents a challenge. In this work, the use of oxygen plasma treatment to improve the wettability and reactivity of the PDMS catheter material and improve adhesion with the EGDPEA–co-DEGMA coating has been investigated. Argon Cluster 3D-imaging Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has been used to probe the buried adhesive interface between the EGDPEA–co-DEGMA coating and the treated PDMS. ToF-SIMS analysis was performed in both dry and frozen-hydrated states and results were compared to mechanical tests. From the ToF-SIMS data we have been able to observe the presence of PDMS, silicates, salt particles, cracks and water at the adhesive interface. In the dry catheters, low molecular weight PDMS oligomers at the interface were associated with poor adhesion. When hydrated, the hydrophilic silicates attracted water to the interface and led to easy delamination of the coating. The best adhesion results, under hydrated conditions, were obtained using a combination of 5 min O2 plasma treatment and silane primers. Cryo-ToF-SIMS analysis of the hydrated catheter material showed that the bond between the primed PDMS catheter and the EGDPEA–co-DEGMA coating was stable in the presence of water. The resulting catheter material was resisted Escherichia coli and Proteus mirabilis biofilm colonization by up to 95 % compared with uncoated PDMS after 10 days of continuous bacterial exposure and had the mechanical properties necessary for use as a urinary catheter. American Vacuum Society 2017-05-10 Article PeerReviewed Tyler, Bonnie J., Hook, Andrew L., Pelster, Andreas, Williams, Paul, Alexander, Morgan R. and Arlinghaus, Heinrich F. (2017) Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating. Biointerphases, 12 (2). 02C412/1-02C412/12. ISSN 1559-4106 Plasma materials processing Adhesion Three dimensional image processing Gravimetric analysis Biofilms http://avs.scitation.org/doi/full/10.1116/1.4984011 doi:10.1116/1.4984011 doi:10.1116/1.4984011 |
| spellingShingle | Plasma materials processing Adhesion Three dimensional image processing Gravimetric analysis Biofilms Tyler, Bonnie J. Hook, Andrew L. Pelster, Andreas Williams, Paul Alexander, Morgan R. Arlinghaus, Heinrich F. Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title | Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title_full | Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title_fullStr | Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title_full_unstemmed | Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title_short | Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| title_sort | development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating |
| topic | Plasma materials processing Adhesion Three dimensional image processing Gravimetric analysis Biofilms |
| url | https://eprints.nottingham.ac.uk/44396/ https://eprints.nottingham.ac.uk/44396/ https://eprints.nottingham.ac.uk/44396/ |