Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation

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Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation

Background: Corn trypsin inhibitor (CTI) has selectivity for serine proteases coagulation factor XII (FXII) and trypsin. CTI is in widespread use as a reagent that specifically inhibits the intrinsic pathway of blood coagulation but not the extrinsic pathway. Objectives: To investigate the molecu...

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Bibliographic Details
Main Authors:	Hamad, Badraldin K., Pathak, Monika, Manna, Rosa, Fischer, Peter M., Emsley, Jonas, Dekker, Lodewijk V.
Format:	Article
Published:	Wiley 2017
Subjects:	corn trypsin inhibitor; factor XII; molecular docking simulation; serine protease; trypsin
Online Access:	https://eprints.nottingham.ac.uk/44393/

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