Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: characterisation by in vitro percutaneous absorption studies and time-of-flight secondary ion mass spectrometry

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: characterisation by in vitro percutaneous absorption studies and time-of-flight secondary ion mass spectrometry

Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobial drug. Franz-type diffusion cell studies using in vitro po...

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Bibliographic Details
Main Authors: Holmes, Amy M., Scurr, David J., Heylings, Jon R., Wan, Ka-Wai, Moss, Gary P.
Format: Article
Published: Elsevier 2017
Subjects:
PAMAM dendrimer; Time-of-Flight Secondary Ion Mass; Spectrometry; Chlorhexidine; In vitro skin diffusion; Tape stripping; Penetration enhancer
Online Access:https://eprints.nottingham.ac.uk/44381/

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