Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forced expiratory volume in 1 second) or FEV1/FVC (FEV...

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Main Authors: Aschard, Hugues, Tobin, Martin D., Hancock, Dana B., Skurnik, David, Sood, Akshay, James, Alan, Vernon Smith, Albert, Manichaikul, Ani W., Campbell, Archie, Prins, Bram P., Hayward, Caroline, Loth, Daan W., Porteous, David J., Strachan, David P., Zeggini, Eleftheria, O’Connor, George T., Brusselle, Guy G., Boezen, H. Marike, Schulz, Holger, Deary, Ian J., Hall, Ian P., Rudan, Igor, Kaprio, Jaakko, Wilson, James F., Wilk, Jemma B., Huffman, Jennifer E., Hua Zhao, Jing, de Jong, Kim, Lyytikäinen, Leo-Pekka, Wain, Louise V., Jarvelin, Marjo-Riitta, Kähönen, Mika, Fornage, Myriam, Polasek, Ozren, Cassano, Patricia A., Barr, R. Graham, Rawal, Rajesh, Harris, Sarah E., Gharib, Sina A., Enroth, Stefan, Heckbert, Susan R., Lehtimäki, Terho, Gyllensten, Ulf, Gudnason, Vilmundur, Jackson, Victoria E., Tang, Wenbo, Dupuis, Josée, Soler Artigas, María, Joshi, Amit D., London, Stephanie J., Kraft, Peter
Format: Article
Published: Oxford University Press 2017
Online Access:https://eprints.nottingham.ac.uk/44358/

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