Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system
Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiogenesis and vascularisation. We hypothesised that...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/44329/ |
| _version_ | 1848796891744043008 |
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| author | Kurlak, L.O. Williams, Paula Juliet Bulmer, Judith N. Broughton Pipkin, Fiona Mistry, Hiten D. |
| author_facet | Kurlak, L.O. Williams, Paula Juliet Bulmer, Judith N. Broughton Pipkin, Fiona Mistry, Hiten D. |
| author_sort | Kurlak, L.O. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiogenesis and vascularisation. We hypothesised that placental adenosine A2AR receptor and HIF-1α would change through pregnancy in association with the RAS. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations; at delivery from normotensive (NT) and PE pregnancy. Results were compared to our previously reported data on the angiotensin receptors: AT1R, AT2R and AT4R.
Protein expression of both A2AR and HIF-1α was highest in early TOP and positively correlated through pregnancy (P<0.0001): expression was higher in PE than NT at delivery (P<0.0001 for both). The A2AR positively correlated with the AT4R in placentae in early pregnancy (r=0.53; P=0.035), but not in 3rd trimester samples. Our findings suggest a role for adenosine and RAS in promoting placentation and as a potential adaptation to poor placental perfusion in pre-eclampsia. |
| first_indexed | 2025-11-14T19:55:11Z |
| format | Article |
| id | nottingham-44329 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:11Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-443292024-08-15T15:32:46Z https://eprints.nottingham.ac.uk/44329/ Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system Kurlak, L.O. Williams, Paula Juliet Bulmer, Judith N. Broughton Pipkin, Fiona Mistry, Hiten D. Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiogenesis and vascularisation. We hypothesised that placental adenosine A2AR receptor and HIF-1α would change through pregnancy in association with the RAS. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations; at delivery from normotensive (NT) and PE pregnancy. Results were compared to our previously reported data on the angiotensin receptors: AT1R, AT2R and AT4R. Protein expression of both A2AR and HIF-1α was highest in early TOP and positively correlated through pregnancy (P<0.0001): expression was higher in PE than NT at delivery (P<0.0001 for both). The A2AR positively correlated with the AT4R in placentae in early pregnancy (r=0.53; P=0.035), but not in 3rd trimester samples. Our findings suggest a role for adenosine and RAS in promoting placentation and as a potential adaptation to poor placental perfusion in pre-eclampsia. Elsevier 2015-05 Article PeerReviewed Kurlak, L.O., Williams, Paula Juliet, Bulmer, Judith N., Broughton Pipkin, Fiona and Mistry, Hiten D. (2015) Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36 (5). pp. 611-613. ISSN 1532-3102 Placental A2AR; HIF-1α: angiotensin receptors; Early pregnancy; Pre-eclampsia http://www.sciencedirect.com/science/article/pii/S0143400415008103 doi:10.1016/j.placenta.2015.02.011 doi:10.1016/j.placenta.2015.02.011 |
| spellingShingle | Placental A2AR; HIF-1α: angiotensin receptors; Early pregnancy; Pre-eclampsia Kurlak, L.O. Williams, Paula Juliet Bulmer, Judith N. Broughton Pipkin, Fiona Mistry, Hiten D. Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title | Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title_full | Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title_fullStr | Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title_full_unstemmed | Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title_short | Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| title_sort | placental expression of adenosine a2a receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system |
| topic | Placental A2AR; HIF-1α: angiotensin receptors; Early pregnancy; Pre-eclampsia |
| url | https://eprints.nottingham.ac.uk/44329/ https://eprints.nottingham.ac.uk/44329/ https://eprints.nottingham.ac.uk/44329/ |