Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia
Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/44328/ |
| _version_ | 1848796891441004544 |
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| author | Smith-Jackson, Kate Hentschke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Broughton Pipkin, Fiona Czajka, Anna Mistry, Hiten D. |
| author_facet | Smith-Jackson, Kate Hentschke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Broughton Pipkin, Fiona Czajka, Anna Mistry, Hiten D. |
| author_sort | Smith-Jackson, Kate |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. |
| first_indexed | 2025-11-14T19:55:11Z |
| format | Article |
| id | nottingham-44328 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:11Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-443282024-08-15T15:16:37Z https://eprints.nottingham.ac.uk/44328/ Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia Smith-Jackson, Kate Hentschke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Broughton Pipkin, Fiona Czajka, Anna Mistry, Hiten D. Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. Elsevier 2015-04-01 Article PeerReviewed Smith-Jackson, Kate, Hentschke, Marta, Poli-de-Figueiredo, Carlos, Pinheiro da Costa, Bartira, Broughton Pipkin, Fiona, Czajka, Anna and Mistry, Hiten D. (2015) Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36 (5). pp. 607-610. ISSN 1532-3102 Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta http://www.sciencedirect.com/science/article/pii/S0143400415002684 doi:10.1016/j.placenta.2015.02.001 doi:10.1016/j.placenta.2015.02.001 |
| spellingShingle | Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta Smith-Jackson, Kate Hentschke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Broughton Pipkin, Fiona Czajka, Anna Mistry, Hiten D. Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title_full | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title_fullStr | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title_full_unstemmed | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title_short | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
| title_sort | placental expression of enos, inos and the major protein components of caveolae in women with pre-eclampsia |
| topic | Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta |
| url | https://eprints.nottingham.ac.uk/44328/ https://eprints.nottingham.ac.uk/44328/ https://eprints.nottingham.ac.uk/44328/ |