Expression of voltage-dependent potassium channels in first trimester human placentae
Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/44325/ |
| _version_ | 1848796890604240896 |
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| author | Mistry, Hiten D. Kurlak, L.O. Whitley, Guy S. Cartwright, Judith E. Broughton Pipkin, Fiona Tribe, Rachel M. |
| author_facet | Mistry, Hiten D. Kurlak, L.O. Whitley, Guy S. Cartwright, Judith E. Broughton Pipkin, Fiona Tribe, Rachel M. |
| author_sort | Mistry, Hiten D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae. |
| first_indexed | 2025-11-14T19:55:10Z |
| format | Article |
| id | nottingham-44325 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:10Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-443252024-08-15T15:15:31Z https://eprints.nottingham.ac.uk/44325/ Expression of voltage-dependent potassium channels in first trimester human placentae Mistry, Hiten D. Kurlak, L.O. Whitley, Guy S. Cartwright, Judith E. Broughton Pipkin, Fiona Tribe, Rachel M. Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae. Elsevier 2014-05-31 Article PeerReviewed Mistry, Hiten D., Kurlak, L.O., Whitley, Guy S., Cartwright, Judith E., Broughton Pipkin, Fiona and Tribe, Rachel M. (2014) Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35 (5). pp. 337-340. ISSN 1532-3102 Potassium channel Placenta Early pregnancy KCNQ KCNE http://www.sciencedirect.com/science/article/pii/S0143400414000824 doi:10.1016/j.placenta.2014.02.008 doi:10.1016/j.placenta.2014.02.008 |
| spellingShingle | Potassium channel Placenta Early pregnancy KCNQ KCNE Mistry, Hiten D. Kurlak, L.O. Whitley, Guy S. Cartwright, Judith E. Broughton Pipkin, Fiona Tribe, Rachel M. Expression of voltage-dependent potassium channels in first trimester human placentae |
| title | Expression of voltage-dependent potassium channels in first trimester human placentae |
| title_full | Expression of voltage-dependent potassium channels in first trimester human placentae |
| title_fullStr | Expression of voltage-dependent potassium channels in first trimester human placentae |
| title_full_unstemmed | Expression of voltage-dependent potassium channels in first trimester human placentae |
| title_short | Expression of voltage-dependent potassium channels in first trimester human placentae |
| title_sort | expression of voltage-dependent potassium channels in first trimester human placentae |
| topic | Potassium channel Placenta Early pregnancy KCNQ KCNE |
| url | https://eprints.nottingham.ac.uk/44325/ https://eprints.nottingham.ac.uk/44325/ https://eprints.nottingham.ac.uk/44325/ |