Expression of voltage-dependent potassium channels in first trimester human placentae

Expression of voltage-dependent potassium channels in first trimester human placentae

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental...

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Bibliographic Details
Main Authors: Mistry, Hiten D., Kurlak, L.O., Whitley, Guy S., Cartwright, Judith E., Broughton Pipkin, Fiona, Tribe, Rachel M.
Format: Article
Published: Elsevier 2014
Subjects:
Potassium channel
Placenta
Early pregnancy
KCNQ
KCNE
Online Access:https://eprints.nottingham.ac.uk/44325/
Description
Summary:Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

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