Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype
Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-regulated in pre-eclampsia, associated with increa...
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| Format: | Article |
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American Society for Biochemistry and Molecular Biology
2013
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| Online Access: | https://eprints.nottingham.ac.uk/44322/ |
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| author | Hentchke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Kurlak, L.O. Williams, Paula Juliet Mistry, Hiten D. |
| author_facet | Hentchke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Kurlak, L.O. Williams, Paula Juliet Mistry, Hiten D. |
| author_sort | Hentchke, Marta |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-regulated in pre-eclampsia, associated with increased maternal and fetal lipoprotein concentrations; 2) expression of these would be reduced in pre-eclamptic placentae from women delivering small-for-gestational-age (SGA) infants. Placental biopsies, maternal and umbilical serum samples were taken from 27 normotensive and 24 pre-eclamptic women. Maternal/umbilical cord serum LDL; HDL; total cholesterol and triglycerides were measured. Placental mRNA expression of lipoprotein receptors/transporters were quantified using qRT-PCR. Protein localisation/expression of LRP-1 in the pre-eclamptic with/without SGA was measured by immunohistochemistry. Placental mRNA expression of all genes except PON-1, MTTP and PDIA2 were observed. No differences for any lipoprotein receptors/transporters were found between groups; however, in the pre-eclamptic group placental LRP-1 expression was lower in SGA delivering mothers (n = 7; P=0.036). LRP-1 protein was localised around fetal vessels and Hofbauer cells. This is the first detailed study of maternal/fetal lipoprotein concentrations and placental lipoprotein receptor mRNA expression in normotensive and pre-eclamptic pregnancies. These findings do not support a role of altered lipid metabolism in pre-eclampsia, but may be involved in fetal growth. |
| first_indexed | 2025-11-14T19:55:09Z |
| format | Article |
| id | nottingham-44322 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:55:09Z |
| publishDate | 2013 |
| publisher | American Society for Biochemistry and Molecular Biology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-443222020-05-04T16:39:08Z https://eprints.nottingham.ac.uk/44322/ Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype Hentchke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Kurlak, L.O. Williams, Paula Juliet Mistry, Hiten D. Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-regulated in pre-eclampsia, associated with increased maternal and fetal lipoprotein concentrations; 2) expression of these would be reduced in pre-eclamptic placentae from women delivering small-for-gestational-age (SGA) infants. Placental biopsies, maternal and umbilical serum samples were taken from 27 normotensive and 24 pre-eclamptic women. Maternal/umbilical cord serum LDL; HDL; total cholesterol and triglycerides were measured. Placental mRNA expression of lipoprotein receptors/transporters were quantified using qRT-PCR. Protein localisation/expression of LRP-1 in the pre-eclamptic with/without SGA was measured by immunohistochemistry. Placental mRNA expression of all genes except PON-1, MTTP and PDIA2 were observed. No differences for any lipoprotein receptors/transporters were found between groups; however, in the pre-eclamptic group placental LRP-1 expression was lower in SGA delivering mothers (n = 7; P=0.036). LRP-1 protein was localised around fetal vessels and Hofbauer cells. This is the first detailed study of maternal/fetal lipoprotein concentrations and placental lipoprotein receptor mRNA expression in normotensive and pre-eclamptic pregnancies. These findings do not support a role of altered lipid metabolism in pre-eclampsia, but may be involved in fetal growth. American Society for Biochemistry and Molecular Biology 2013-10-31 Article PeerReviewed Hentchke, Marta, Poli-de-Figueiredo, Carlos, Pinheiro da Costa, Bartira, Kurlak, L.O., Williams, Paula Juliet and Mistry, Hiten D. (2013) Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54 . pp. 2658-2664. ISSN 1539-7262 Hypertension; Lipids; LDL cholesterol; HDL cholesterol; Triglycerides; ABCA1; LRP-1; LDL-R; SRB-1;Fetal growth http://www.jlr.org/content/54/10/2658 doi:10.1194/jlr.M036699 doi:10.1194/jlr.M036699 |
| spellingShingle | Hypertension; Lipids; LDL cholesterol; HDL cholesterol; Triglycerides; ABCA1; LRP-1; LDL-R; SRB-1;Fetal growth Hentchke, Marta Poli-de-Figueiredo, Carlos Pinheiro da Costa, Bartira Kurlak, L.O. Williams, Paula Juliet Mistry, Hiten D. Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title | Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title_full | Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title_fullStr | Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title_full_unstemmed | Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title_short | Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| title_sort | is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype |
| topic | Hypertension; Lipids; LDL cholesterol; HDL cholesterol; Triglycerides; ABCA1; LRP-1; LDL-R; SRB-1;Fetal growth |
| url | https://eprints.nottingham.ac.uk/44322/ https://eprints.nottingham.ac.uk/44322/ https://eprints.nottingham.ac.uk/44322/ |