The placental renin-angiotensin system and oxidative stress in pre-eclampsia
There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, ma...
| Main Authors: | , , |
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| Format: | Article |
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Elsevier
2013
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| Online Access: | https://eprints.nottingham.ac.uk/44270/ |
| _version_ | 1848796877005258752 |
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| author | Mistry, H.D. Kurlak, L.O. Broughton Pipkin, Fiona |
| author_facet | Mistry, H.D. Kurlak, L.O. Broughton Pipkin, Fiona |
| author_sort | Mistry, H.D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, manifests as high blood pressure and proteinuria, and is a state of increased oxidative stress.
Objectives, study design and main outcome measures
Hypothesis: Pre-eclampsia will be associated with increased placental expression of components of the renin–angiotensin system, which could result in reduced infant birthweight. Biopsies were taken 1 cm from the placental edge from 27 normotensive controls and 23 pre-eclamptic White European women. Immunohistochemistry was performed for AGT, PRR, glutathione peroxidase 3 (GPx3) and the AT1R and AT2R AngII receptors. Protein expression was semi-quantitatively assessed (H-score).
Results: AT1R expression was significantly increased in pre-eclamptic placentae, and negatively correlated with birthweight (r = −0.529, P = 0.009). AT1R expression was also negatively correlated with GPx3 expression overall (r = −0.647; P = 0.005). AT2R expression positively correlated with AGT (r = 0.615, P = 0.002) in the pre-eclamptic placentae only.
Conclusions: The raised AT1R expression in pre-eclampsia, together with inadequate antioxidant protection, possibly through lower GPx activity, might enhance the vasoconstrictor effect of locally-generated AngII, contributing to the restricted fetal growth characteristic of pre-eclampsia. Conversely, the AT2R:AGT association within the pre-eclamptic placenta may provide a compensatory mechanism. |
| first_indexed | 2025-11-14T19:54:57Z |
| format | Article |
| id | nottingham-44270 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:57Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-442702020-05-04T16:35:08Z https://eprints.nottingham.ac.uk/44270/ The placental renin-angiotensin system and oxidative stress in pre-eclampsia Mistry, H.D. Kurlak, L.O. Broughton Pipkin, Fiona There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, manifests as high blood pressure and proteinuria, and is a state of increased oxidative stress. Objectives, study design and main outcome measures Hypothesis: Pre-eclampsia will be associated with increased placental expression of components of the renin–angiotensin system, which could result in reduced infant birthweight. Biopsies were taken 1 cm from the placental edge from 27 normotensive controls and 23 pre-eclamptic White European women. Immunohistochemistry was performed for AGT, PRR, glutathione peroxidase 3 (GPx3) and the AT1R and AT2R AngII receptors. Protein expression was semi-quantitatively assessed (H-score). Results: AT1R expression was significantly increased in pre-eclamptic placentae, and negatively correlated with birthweight (r = −0.529, P = 0.009). AT1R expression was also negatively correlated with GPx3 expression overall (r = −0.647; P = 0.005). AT2R expression positively correlated with AGT (r = 0.615, P = 0.002) in the pre-eclamptic placentae only. Conclusions: The raised AT1R expression in pre-eclampsia, together with inadequate antioxidant protection, possibly through lower GPx activity, might enhance the vasoconstrictor effect of locally-generated AngII, contributing to the restricted fetal growth characteristic of pre-eclampsia. Conversely, the AT2R:AGT association within the pre-eclamptic placenta may provide a compensatory mechanism. Elsevier 2013-02-01 Article PeerReviewed Mistry, H.D., Kurlak, L.O. and Broughton Pipkin, Fiona (2013) The placental renin-angiotensin system and oxidative stress in pre-eclampsia. Placenta, 34 (2). pp. 182-186. ISSN 1532-3102 http://www.sciencedirect.com/science/article/pii/S0143400412004626?via%3Dihub doi:10.1016/j.placenta.2012.11.027 doi:10.1016/j.placenta.2012.11.027 |
| spellingShingle | Mistry, H.D. Kurlak, L.O. Broughton Pipkin, Fiona The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title | The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title_full | The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title_fullStr | The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title_full_unstemmed | The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title_short | The placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| title_sort | placental renin-angiotensin system and oxidative stress in pre-eclampsia |
| url | https://eprints.nottingham.ac.uk/44270/ https://eprints.nottingham.ac.uk/44270/ https://eprints.nottingham.ac.uk/44270/ |