The role of oxidative stress and antioxidant supplementation in pregnancy disorders
Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an animal model of maternal obesity we have reported ev...
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| Format: | Article |
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American Society for Nutrition
2011
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| Online Access: | https://eprints.nottingham.ac.uk/44262/ |
| _version_ | 1848796874828414976 |
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| author | Poston, Lucilla Igosheva, Natalia Mistry, Hiten D. Seed, Paul T. Shennan, Andrew H. Rana, Sarosh Karumanchi, S. Ananth Chappell, Lucy C. |
| author_facet | Poston, Lucilla Igosheva, Natalia Mistry, Hiten D. Seed, Paul T. Shennan, Andrew H. Rana, Sarosh Karumanchi, S. Ananth Chappell, Lucy C. |
| author_sort | Poston, Lucilla |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an animal model of maternal obesity we have reported evidence of oxidative stress in the oocytes of obese animals prior to pregnancy as well as in early stage embryos. This adds to the growing evidence for a greater focus on the pre-conceptual period in prevention of pregnancy disorders including those related to oxidative stress. Our research has also focussed on the role of free radicals and antioxidant capacity in preeclampsia. Assessment by measurement of markers of lipid peroxidation or of antioxidant capacity has provided unequivocal evidence for oxidative stress in this disorder. Partial failure of the process of placentation has been implicated, with recent evidence proposing that ischaemia-reperfusion in the placenta may contribute to oxidative stress in trophoblast. Endoplasmic reticulum stress in the placenta may also play a role. We and others have performed randomised controlled trials to determine whether early supplementation with vitamins C and E in women at risk of preeclampsia may be beneficial but these studies have shown no evidence for prevention of preeclampsia. Whether this represents an inappropriate antioxidant strategy or whether supplementation has been too late in gestation to be beneficial is not known. Other potential approaches to prevention of preeclampsia through amelioration of oxidative stress include provision of supplements in the pre-conceptual period, selenium supplements, anti-peroxynitrite strategies and statins. |
| first_indexed | 2025-11-14T19:54:55Z |
| format | Article |
| id | nottingham-44262 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:55Z |
| publishDate | 2011 |
| publisher | American Society for Nutrition |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-442622020-05-04T16:31:35Z https://eprints.nottingham.ac.uk/44262/ The role of oxidative stress and antioxidant supplementation in pregnancy disorders Poston, Lucilla Igosheva, Natalia Mistry, Hiten D. Seed, Paul T. Shennan, Andrew H. Rana, Sarosh Karumanchi, S. Ananth Chappell, Lucy C. Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an animal model of maternal obesity we have reported evidence of oxidative stress in the oocytes of obese animals prior to pregnancy as well as in early stage embryos. This adds to the growing evidence for a greater focus on the pre-conceptual period in prevention of pregnancy disorders including those related to oxidative stress. Our research has also focussed on the role of free radicals and antioxidant capacity in preeclampsia. Assessment by measurement of markers of lipid peroxidation or of antioxidant capacity has provided unequivocal evidence for oxidative stress in this disorder. Partial failure of the process of placentation has been implicated, with recent evidence proposing that ischaemia-reperfusion in the placenta may contribute to oxidative stress in trophoblast. Endoplasmic reticulum stress in the placenta may also play a role. We and others have performed randomised controlled trials to determine whether early supplementation with vitamins C and E in women at risk of preeclampsia may be beneficial but these studies have shown no evidence for prevention of preeclampsia. Whether this represents an inappropriate antioxidant strategy or whether supplementation has been too late in gestation to be beneficial is not known. Other potential approaches to prevention of preeclampsia through amelioration of oxidative stress include provision of supplements in the pre-conceptual period, selenium supplements, anti-peroxynitrite strategies and statins. American Society for Nutrition 2011-12-01 Article PeerReviewed Poston, Lucilla, Igosheva, Natalia, Mistry, Hiten D., Seed, Paul T., Shennan, Andrew H., Rana, Sarosh, Karumanchi, S. Ananth and Chappell, Lucy C. (2011) The role of oxidative stress and antioxidant supplementation in pregnancy disorders. American Journal of Clinical Nutrition, 94 (6Suppl). 1980S-1985S. ISSN 1938-3207 http://ajcn.nutrition.org/content/94/6_Suppl/1980S doi:10.3945/ajcn.110.001156 doi:10.3945/ajcn.110.001156 |
| spellingShingle | Poston, Lucilla Igosheva, Natalia Mistry, Hiten D. Seed, Paul T. Shennan, Andrew H. Rana, Sarosh Karumanchi, S. Ananth Chappell, Lucy C. The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title | The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title_full | The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title_fullStr | The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title_full_unstemmed | The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title_short | The role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| title_sort | role of oxidative stress and antioxidant supplementation in pregnancy disorders |
| url | https://eprints.nottingham.ac.uk/44262/ https://eprints.nottingham.ac.uk/44262/ https://eprints.nottingham.ac.uk/44262/ |