Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study
Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality. Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first yea...
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| Format: | Article |
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Cancer Research UK
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44245/ |
| _version_ | 1848796870591119360 |
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| author | Koshiaris, C. Aveyard, P. Oke, J. Ryan, R. Szatkowski, Lisa Stevens, R. Farley, A. |
| author_facet | Koshiaris, C. Aveyard, P. Oke, J. Ryan, R. Szatkowski, Lisa Stevens, R. Farley, A. |
| author_sort | Koshiaris, C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality.
Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first year after diagnosis and all-cause and cancer- specific mortality.
Results: Of 2,882 lung, 757 upper aero-digestive tract and 1,733 bladder cancer patients 27%, 29% and 21% of lung, UAT and bladder cancer patients quit smoking. In lung cancer patients that quit, all-cause mortality was significantly lower (HR 0.82 (0.74-0.92), while cancer-specific mortality (HR 0.89 (0.76-1.04) and death due to index cancer (HR 0.90 (0.77-1.05) were nonsignificantly lower. In UAT cancer, all-cause mortality (HR 0.81 (0.58-1.14), cancer-specific mortality (HR 0.84 (0.48-1.45), and death due to index cancer (HR 0.75 (0.42-1.34) were non-significantly lower. There was no evidence of an association between quitting and mortality in bladder cancer. The HRs were 1.02 (0.81 1.30) for all-cause, 1.23 (0.81-1.86) for cancer specific, and 1.25 (0.71-2.20) for death due to index cancer. These showed a nonsignificantly lower risk in sensitivity analyses.
Conclusion: People with lung and possibly UAT cancer who quit smoking have a lower risk of mortality than people who continue smoking. |
| first_indexed | 2025-11-14T19:54:51Z |
| format | Article |
| id | nottingham-44245 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:51Z |
| publishDate | 2017 |
| publisher | Cancer Research UK |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-442452020-05-04T19:06:25Z https://eprints.nottingham.ac.uk/44245/ Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study Koshiaris, C. Aveyard, P. Oke, J. Ryan, R. Szatkowski, Lisa Stevens, R. Farley, A. Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality. Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first year after diagnosis and all-cause and cancer- specific mortality. Results: Of 2,882 lung, 757 upper aero-digestive tract and 1,733 bladder cancer patients 27%, 29% and 21% of lung, UAT and bladder cancer patients quit smoking. In lung cancer patients that quit, all-cause mortality was significantly lower (HR 0.82 (0.74-0.92), while cancer-specific mortality (HR 0.89 (0.76-1.04) and death due to index cancer (HR 0.90 (0.77-1.05) were nonsignificantly lower. In UAT cancer, all-cause mortality (HR 0.81 (0.58-1.14), cancer-specific mortality (HR 0.84 (0.48-1.45), and death due to index cancer (HR 0.75 (0.42-1.34) were non-significantly lower. There was no evidence of an association between quitting and mortality in bladder cancer. The HRs were 1.02 (0.81 1.30) for all-cause, 1.23 (0.81-1.86) for cancer specific, and 1.25 (0.71-2.20) for death due to index cancer. These showed a nonsignificantly lower risk in sensitivity analyses. Conclusion: People with lung and possibly UAT cancer who quit smoking have a lower risk of mortality than people who continue smoking. Cancer Research UK 2017-09-12 Article PeerReviewed Koshiaris, C., Aveyard, P., Oke, J., Ryan, R., Szatkowski, Lisa, Stevens, R. and Farley, A. (2017) Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study. British Journal of Cancer, 117 . pp. 1224-1232. ISSN 1532-1827 Smoking Smoking cessation Cancer Primary care http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017179a.html doi:10.1038/bjc.2017.179 doi:10.1038/bjc.2017.179 |
| spellingShingle | Smoking Smoking cessation Cancer Primary care Koshiaris, C. Aveyard, P. Oke, J. Ryan, R. Szatkowski, Lisa Stevens, R. Farley, A. Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title | Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title_full | Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title_fullStr | Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title_full_unstemmed | Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title_short | Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| title_sort | smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study |
| topic | Smoking Smoking cessation Cancer Primary care |
| url | https://eprints.nottingham.ac.uk/44245/ https://eprints.nottingham.ac.uk/44245/ https://eprints.nottingham.ac.uk/44245/ |