Ovarian reserve after salpingectomy: a systematic review and meta-analysis
Introduction Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. Material and methods A de...
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| Format: | Article |
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44241/ |
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| author | Mohamed, Ahmed Aboelfadle Yosef, Ali Haroun James, Cathryn Al-Hussaini, Tarek Khalaf Bedaiwy, Mohamed Ali Amer, Saad A. |
| author_facet | Mohamed, Ahmed Aboelfadle Yosef, Ali Haroun James, Cathryn Al-Hussaini, Tarek Khalaf Bedaiwy, Mohamed Ali Amer, Saad A. |
| author_sort | Mohamed, Ahmed Aboelfadle |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction
Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve.
Material and methods
A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154).
Results
Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, −0.10 ng/mL; 95% CI −0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, −0.11 ng/mL; 95% CI −0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (<40 years) still showed no statistically significant changes in circulating AMH.
Conclusion
Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain. |
| first_indexed | 2025-11-14T19:54:50Z |
| format | Article |
| id | nottingham-44241 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:50Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-442412024-08-15T15:22:54Z https://eprints.nottingham.ac.uk/44241/ Ovarian reserve after salpingectomy: a systematic review and meta-analysis Mohamed, Ahmed Aboelfadle Yosef, Ali Haroun James, Cathryn Al-Hussaini, Tarek Khalaf Bedaiwy, Mohamed Ali Amer, Saad A. Introduction Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. Material and methods A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154). Results Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, −0.10 ng/mL; 95% CI −0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, −0.11 ng/mL; 95% CI −0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (<40 years) still showed no statistically significant changes in circulating AMH. Conclusion Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain. Wiley 2017-06-20 Article PeerReviewed Mohamed, Ahmed Aboelfadle, Yosef, Ali Haroun, James, Cathryn, Al-Hussaini, Tarek Khalaf, Bedaiwy, Mohamed Ali and Amer, Saad A. (2017) Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 96 (7). pp. 795-803. ISSN 1600-0412 Salpingectomy Ovarian reserve Anti-Müllerian hormone Ovarian function Laparoscopy https://doi.org/10.1111/aogs.13133 doi:10.1111/aogs.13133 doi:10.1111/aogs.13133 |
| spellingShingle | Salpingectomy Ovarian reserve Anti-Müllerian hormone Ovarian function Laparoscopy Mohamed, Ahmed Aboelfadle Yosef, Ali Haroun James, Cathryn Al-Hussaini, Tarek Khalaf Bedaiwy, Mohamed Ali Amer, Saad A. Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title | Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title_full | Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title_fullStr | Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title_full_unstemmed | Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title_short | Ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| title_sort | ovarian reserve after salpingectomy: a systematic review and meta-analysis |
| topic | Salpingectomy Ovarian reserve Anti-Müllerian hormone Ovarian function Laparoscopy |
| url | https://eprints.nottingham.ac.uk/44241/ https://eprints.nottingham.ac.uk/44241/ https://eprints.nottingham.ac.uk/44241/ |