sTREM-1 is elevated in cystic fibrosis and correlates with proteases
Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic be...
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44121/ |
| _version_ | 1848796843435098112 |
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| author | Forrester, D.L. Barr, Helen L. Fogarty, Andrew W. Knox, A. |
| author_facet | Forrester, D.L. Barr, Helen L. Fogarty, Andrew W. Knox, A. |
| author_sort | Forrester, D.L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic benefit. We hypothesised that sTREM-1 could act as a biomarker of disease in cystic fibrosis.
Methods: Plasma from 17 patients with CF (stable and pre and post pulmonary exacerbation) and eight healthy volunteers was analyzed for sTREM-1 and proteases (matrix metalloproteinase-8 (MMP-8), MMP-9, and human neutrophil elastase HNE).
Results: sTREM-1 Levels were elevated in stable CF subjects compared to controls (148 pg/ml (130–160) [median(IQR)] vs. 87 (55–118) (P < 0.01)) but were not further increased during pulmonary exacerbation nor decreased after antibiotic treatment in CF. Protease levels were increased in CF plasma compared to controls: MMP–8 = 3.1 ng/ml (1.5–7.6) vs. 0.3 (0.18–0.53) (P < 0.01) (Wilcoxon); MMP–9 = 170 ng/ml (124–282) vs. 49 (39–90) (P < 0.01); HNE = 30.2 ng/ml (22.7–30.9) vs. 17.5 (11.2–22.2) (P < 0.05). sTREM-1 correlated positively with protease levels lnMMP-8 r2 = 0.55 (P = 0.08), lnMMP-9 r2 = 0.61(P < 0.05), lnHNE r2 = 0.35 (P < 0.05).
Conclusions: sTREM-1 is constitutively elevated in CF and positively correlates with protease levels. Modulation of this pathway may be of therapeutic benefit to patients with CF. |
| first_indexed | 2025-11-14T19:54:25Z |
| format | Article |
| id | nottingham-44121 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:25Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-441212024-08-15T15:21:35Z https://eprints.nottingham.ac.uk/44121/ sTREM-1 is elevated in cystic fibrosis and correlates with proteases Forrester, D.L. Barr, Helen L. Fogarty, Andrew W. Knox, A. Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic benefit. We hypothesised that sTREM-1 could act as a biomarker of disease in cystic fibrosis. Methods: Plasma from 17 patients with CF (stable and pre and post pulmonary exacerbation) and eight healthy volunteers was analyzed for sTREM-1 and proteases (matrix metalloproteinase-8 (MMP-8), MMP-9, and human neutrophil elastase HNE). Results: sTREM-1 Levels were elevated in stable CF subjects compared to controls (148 pg/ml (130–160) [median(IQR)] vs. 87 (55–118) (P < 0.01)) but were not further increased during pulmonary exacerbation nor decreased after antibiotic treatment in CF. Protease levels were increased in CF plasma compared to controls: MMP–8 = 3.1 ng/ml (1.5–7.6) vs. 0.3 (0.18–0.53) (P < 0.01) (Wilcoxon); MMP–9 = 170 ng/ml (124–282) vs. 49 (39–90) (P < 0.01); HNE = 30.2 ng/ml (22.7–30.9) vs. 17.5 (11.2–22.2) (P < 0.05). sTREM-1 correlated positively with protease levels lnMMP-8 r2 = 0.55 (P = 0.08), lnMMP-9 r2 = 0.61(P < 0.05), lnHNE r2 = 0.35 (P < 0.05). Conclusions: sTREM-1 is constitutively elevated in CF and positively correlates with protease levels. Modulation of this pathway may be of therapeutic benefit to patients with CF. Wiley 2017-01-09 Article PeerReviewed Forrester, D.L., Barr, Helen L., Fogarty, Andrew W. and Knox, A. (2017) sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52 (4). pp. 467-471. ISSN 1099-0496 inflammation MMPs biomarkers http://onlinelibrary.wiley.com/doi/10.1002/ppul.23650/abstract doi:10.1002/ppul.23650 doi:10.1002/ppul.23650 |
| spellingShingle | inflammation MMPs biomarkers Forrester, D.L. Barr, Helen L. Fogarty, Andrew W. Knox, A. sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title | sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title_full | sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title_fullStr | sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title_full_unstemmed | sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title_short | sTREM-1 is elevated in cystic fibrosis and correlates with proteases |
| title_sort | strem-1 is elevated in cystic fibrosis and correlates with proteases |
| topic | inflammation MMPs biomarkers |
| url | https://eprints.nottingham.ac.uk/44121/ https://eprints.nottingham.ac.uk/44121/ https://eprints.nottingham.ac.uk/44121/ |