Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease
Background: Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in ho...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/44095/ |
| _version_ | 1848796836872060928 |
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| author | Skelly, Rob Brown, Lisa Fogarty, Andrew W. |
| author_facet | Skelly, Rob Brown, Lisa Fogarty, Andrew W. |
| author_sort | Skelly, Rob |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital.
Methods: The study population consisted of all urgent hospitalizations for patients with a diagnosis of PD to the Royal Derby Hospital over a two-year period. Data were extracted on timing of delivery of drugs, number of co-morbidities and length of stay. Statistical analysis used linear regression adjusting for within admission clustering.
Results: 431 individuals provided data from a total of 737 admissions. 39% of scheduled l-dopa doses were either not given or administered over 30 min later than the scheduled time. There was no association between the omission or timing of a dose of PD medication and length of stay in hospital. The number of coded diagnoses was strongly associated with length of stay with a dose-response association (pTREND<0.001). Those with 10 concurrent diagnoses had a 11 day longer stay (95% confidence intervals: +2 to +21) than those with no comorbidities.
Conclusions Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of in patients with PD who were admitted to hospital as an emergency. However, the number of co-existing medical diagnoses was associated with length of stay, and early attention to these has the potential to improve patient care and decrease length of stay in hospital. |
| first_indexed | 2025-11-14T19:54:19Z |
| format | Article |
| id | nottingham-44095 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:19Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-440952020-05-04T18:33:17Z https://eprints.nottingham.ac.uk/44095/ Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease Skelly, Rob Brown, Lisa Fogarty, Andrew W. Background: Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. Methods: The study population consisted of all urgent hospitalizations for patients with a diagnosis of PD to the Royal Derby Hospital over a two-year period. Data were extracted on timing of delivery of drugs, number of co-morbidities and length of stay. Statistical analysis used linear regression adjusting for within admission clustering. Results: 431 individuals provided data from a total of 737 admissions. 39% of scheduled l-dopa doses were either not given or administered over 30 min later than the scheduled time. There was no association between the omission or timing of a dose of PD medication and length of stay in hospital. The number of coded diagnoses was strongly associated with length of stay with a dose-response association (pTREND<0.001). Those with 10 concurrent diagnoses had a 11 day longer stay (95% confidence intervals: +2 to +21) than those with no comorbidities. Conclusions Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of in patients with PD who were admitted to hospital as an emergency. However, the number of co-existing medical diagnoses was associated with length of stay, and early attention to these has the potential to improve patient care and decrease length of stay in hospital. Elsevier 2017-02-28 Article PeerReviewed Skelly, Rob, Brown, Lisa and Fogarty, Andrew W. (2017) Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease. Parkinsonism & Related Disorders, 35 . pp. 25-29. ISSN 1873-5126 Parkinson's disease Medication L-dopa Delay Length of stay http://www.sciencedirect.com/science/article/pii/S1353802016304357 doi:10.1016/j.parkreldis.2016.11.004 doi:10.1016/j.parkreldis.2016.11.004 |
| spellingShingle | Parkinson's disease Medication L-dopa Delay Length of stay Skelly, Rob Brown, Lisa Fogarty, Andrew W. Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title | Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title_full | Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title_fullStr | Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title_full_unstemmed | Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title_short | Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease |
| title_sort | delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with parkinson's disease |
| topic | Parkinson's disease Medication L-dopa Delay Length of stay |
| url | https://eprints.nottingham.ac.uk/44095/ https://eprints.nottingham.ac.uk/44095/ https://eprints.nottingham.ac.uk/44095/ |