Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster
FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The aim of this study was to investigate whether the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Publishing Group
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/44049/ |
| _version_ | 1848796825085018112 |
|---|---|
| author | Lewis, Jo E. Samms, Ricardo J. Cooper, Scott Luckett, Jeni C. Perkins, Alan C. Adams, Andrew C. Tsintzas, Kostas Ebling, Francis J.P. |
| author_facet | Lewis, Jo E. Samms, Ricardo J. Cooper, Scott Luckett, Jeni C. Perkins, Alan C. Adams, Andrew C. Tsintzas, Kostas Ebling, Francis J.P. |
| author_sort | Lewis, Jo E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The aim of this study was to investigate whether the beneficial effects of a novel mimetic of FGF21 in the LD state are a consequence of increased adiposity or of the central photoperiodic state. This was achieved by investigating effects of FGF21 in aged hamsters, which is associated with reduced adiposity. In LD hamsters with increased adiposity, FGF21 lowered body weight as a result of both reduced daily food intake and increased caloric expenditure, driven by an increase in whole-body fat oxidation. However, in LD animals with reduced adiposity, the effect of FGF21 on body weight, caloric intake and fat oxidation were significantly attenuated or absent when compared to those with increased adiposity. These attenuated/absent effects were underpinned by the inability of FGF21 to increase the expression of key thermogenic genes in interscapular and visceral WAT. Our study demonstrates the efficacy of a novel FGF21 mimetic in hamsters, but reveals attenuated effects in the animal model where adiposity is reduced naturally independent of photoperiod. |
| first_indexed | 2025-11-14T19:54:08Z |
| format | Article |
| id | nottingham-44049 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:54:08Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-440492020-05-04T18:51:51Z https://eprints.nottingham.ac.uk/44049/ Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster Lewis, Jo E. Samms, Ricardo J. Cooper, Scott Luckett, Jeni C. Perkins, Alan C. Adams, Andrew C. Tsintzas, Kostas Ebling, Francis J.P. FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The aim of this study was to investigate whether the beneficial effects of a novel mimetic of FGF21 in the LD state are a consequence of increased adiposity or of the central photoperiodic state. This was achieved by investigating effects of FGF21 in aged hamsters, which is associated with reduced adiposity. In LD hamsters with increased adiposity, FGF21 lowered body weight as a result of both reduced daily food intake and increased caloric expenditure, driven by an increase in whole-body fat oxidation. However, in LD animals with reduced adiposity, the effect of FGF21 on body weight, caloric intake and fat oxidation were significantly attenuated or absent when compared to those with increased adiposity. These attenuated/absent effects were underpinned by the inability of FGF21 to increase the expression of key thermogenic genes in interscapular and visceral WAT. Our study demonstrates the efficacy of a novel FGF21 mimetic in hamsters, but reveals attenuated effects in the animal model where adiposity is reduced naturally independent of photoperiod. Nature Publishing Group 2017-06-26 Article PeerReviewed Lewis, Jo E., Samms, Ricardo J., Cooper, Scott, Luckett, Jeni C., Perkins, Alan C., Adams, Andrew C., Tsintzas, Kostas and Ebling, Francis J.P. (2017) Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. Scientific Reports, 7 (1). 4238/1-4238/11. ISSN 2045-2322 Fat metabolism Metabolic syndrome https://doi.org/10.1038/s41598-017-03607-x doi:10.1038/s41598-017-03607-x doi:10.1038/s41598-017-03607-x |
| spellingShingle | Fat metabolism Metabolic syndrome Lewis, Jo E. Samms, Ricardo J. Cooper, Scott Luckett, Jeni C. Perkins, Alan C. Adams, Andrew C. Tsintzas, Kostas Ebling, Francis J.P. Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title_full | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title_fullStr | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title_full_unstemmed | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title_short | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster |
| title_sort | reduced adiposity attenuates fgf21 mediated metabolic improvements in the siberian hamster |
| topic | Fat metabolism Metabolic syndrome |
| url | https://eprints.nottingham.ac.uk/44049/ https://eprints.nottingham.ac.uk/44049/ https://eprints.nottingham.ac.uk/44049/ |