Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses
Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clad...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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American Society for Microbiology
2014
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| Online Access: | https://eprints.nottingham.ac.uk/43921/ |
| _version_ | 1848796796820652032 |
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| author | Sun, H. Sun, Y. Pu, J. Zhang, Y. Zhu, Q. Li, J. Gu, J. Chang, K.-C. Liu, J. |
| author_facet | Sun, H. Sun, Y. Pu, J. Zhang, Y. Zhu, Q. Li, J. Gu, J. Chang, K.-C. Liu, J. |
| author_sort | Sun, H. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response. |
| first_indexed | 2025-11-14T19:53:41Z |
| format | Article |
| id | nottingham-43921 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:53:41Z |
| publishDate | 2014 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-439212020-05-04T16:42:20Z https://eprints.nottingham.ac.uk/43921/ Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses Sun, H. Sun, Y. Pu, J. Zhang, Y. Zhu, Q. Li, J. Gu, J. Chang, K.-C. Liu, J. Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response. American Society for Microbiology 2014-01-03 Article PeerReviewed Sun, H., Sun, Y., Pu, J., Zhang, Y., Zhu, Q., Li, J., Gu, J., Chang, K.-C. and Liu, J. (2014) Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. Journal of Virology, 88 (1). pp. 725-729. ISSN 0022-538X http://jvi.asm.org/content/88/1/725 doi:10.1128/JVI.02510-13 doi:10.1128/JVI.02510-13 |
| spellingShingle | Sun, H. Sun, Y. Pu, J. Zhang, Y. Zhu, Q. Li, J. Gu, J. Chang, K.-C. Liu, J. Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title | Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title_full | Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title_fullStr | Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title_full_unstemmed | Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title_short | Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses |
| title_sort | comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza h5n1 viruses |
| url | https://eprints.nottingham.ac.uk/43921/ https://eprints.nottingham.ac.uk/43921/ https://eprints.nottingham.ac.uk/43921/ |