In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats

QR Code

In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats

Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD...

Full description

Bibliographic Details
Main Authors:	Wheal, Amanda J., Jadoon, Khalid, Randall, Michael D., O'Sullivan, Saoirse
Format:	Article
Published:	Frontiers Media 2017
Subjects:	cannabinoid sodium nitroprusside vasorelaxation nitric oxide cyclooxygenase ZDF rats
Online Access:	https://eprints.nottingham.ac.uk/43898/

Similar Items

The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries
by: Stanley, Christopher P., et al.
Published: (2016)

The actions of cannabidiol and palmitoylethanolamide on inflammation and permeability of the gut
by: Couch, Daniel
Published: (2018)

An investigation into the pharmacological effects of phytocannabinoids and endocannaboids in human mesenteric arteries
by: Stanley, Christopher Peter
Published: (2013)

Bidirectional effects of cannabidiol on contextual fear memory extinction
by: Song, Chenchen, et al.
Published: (2016)

Syntheses and structure-activity relationship studies of schwarzinicine alkaloids as vasorelaxant agents
by: Lee, Fong Kai
Published: (2020)

Changes of NO in rats exposed to CS2
by: Jiang, D., et al.
Published: (2001)

Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase
by: Donovan, J., et al.
Published: (2018)

The use of cannabinoids in colitis: a systematic review and meta-analysis
by: Couch, Daniel G., et al.
Published: (2018)

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
by: Jadoon, Khalid A., et al.
Published: (2017)

Cannabinoids in experimental stroke: a systematic review and meta-analysis
by: England, Timothy J., et al.
Published: (2015)

An investigation into the metabolic and cardiovascular effects of phytocannabinoids using in vivo and in vitro techniques
by: Jadoon, K.A.
Published: (2016)

Endocannabinoid metabolism and peroxisome proliferator-activated receptor signalling
by: Dionisi, Mauro
Published: (2010)

A 23Na NMR study on the environment and mobility of sodium ions in complex food matrices and model systems
by: Shao, Jiaqian
Published: (2019)

Endothelium-dependent vasorelaxation effects of F5 fraction of Crinum amabile chloroform extract
by: Lim, Chung Pin, et al.
Published: (2023)

The changing function of nitric oxide in the ventral cochlear nucleus during tinnitus
by: Hockley, Adam
Published: (2019)

A systematic review and meta-analysis of the haemodynamic effects of cannabidiol
by: Sultan, Salahaden R., et al.
Published: (2017)

Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon
by: Couch, Daniel G., et al.
Published: (2017)

Contribution of intestinal lymphatic transport to the antiproliferative effect of delta-9-tetrahydrocannabinol
by: Wong, Jonathan Chi Man
Published: (2017)

Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed
by: Henry Ginjom, Irine Runnie, et al.
Published: (2004)

Toxicity effects of curcumin analogue, 2, 6-BIS (2-fluorobenzylidene) cyclohexanone on zebrafish (Danio rerio F. Hamilton, 1822)
by: Nazarudin, Nur Amiza
Published: (2017)

Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)

The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)

Delivery of cannabinoids to specific anatomical regions of the brain following oral administration to reach the site of action for glioblastoma multiforme and multiple sclerosis
by: Brookes, Alice
Published: (2023)

Neurotherapeutic potential of synthetic cannabinoid receptor agonist, WIN55,212-2 on Aluminium chloride and D-galactose- induced cognitive impairments in male Wistar rats
by: Onesimus, Mahdi
Published: (2021)

The effect of sodium on cardio-respiratory health
by: Pogson, Zara
Published: (2009)

Removal of Lead (II) By Nitric Acid-Modified Activated Carbon
by: Loo, Li Yin
Published: (2006)

Effects of NAD at purine receptors in isolated blood vessels
by: Alefishat, Eman, et al.
Published: (2015)

Evaluation of curcumin derivatives as new cyclooxygenase-2 inhibitors via in silico and in vitro analyses
by: Abdul Bahari, Mohammad Nazri
Published: (2016)

A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries
by: Mathewson, Alastair M., et al.
Published: (2014)

Learned fear extinction: an interdisciplinary investigation of the neurocircuitry and the potential therapeutic benefit of cannabidiol
by: Jurkus, Regimantas
Published: (2019)

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries
by: Wong, P.S., et al.
Published: (2014)

Patterns of synthetic cannabinoid use in Australia
by: Barratt, Monica, et al.
Published: (2012)

Studies On The Effect Of Benzo(a)Pyrene In Rats
by: Thoria, Ali Abdul Hameed Dragh
Published: (2001)

Isolation and identification of PLC-zeta (a sperm factor protein responsible for embryonic development) in paddy rats.
by: Sukardi, Sabrina, et al.
Published: (2008)

Aphrodisiac potential of the aqueous extract of melicope pteleifolia (Champ ex benth) t. g. hartley in sprague dawley rats
by: Mohd Najib, Nazizarini
Published: (2019)

Functional analysis of nitric oxide in Musa sp. cv. Berangan during interaction with Fusarium oxysporum f. sp. cubense Tropical Race 4
by: Mohd Nasir, Nurul Najihah
Published: (2018)

Synthetic cannabis: A comparison of patterns of use and effect profile with natural cannabis in a large global sample
by: Winstock, A., et al.
Published: (2013)

Endothelium-dependent vasorelaxation and antiproliferation activities of chloroform extract F5 fraction from Crinum amabile Donn ex Ker Gawl. leaves
by: Lim, Chung Pin
Published: (2019)

Efficacy and safety of Cannabidiol and Tetrahydrocannabivarin on glycemic and lipid parameters in patients with Type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study
by: Jadoon, Khalid A., et al.
Published: (2016)

Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity
by: Mahadevan, Vaikom, et al.
Published: (2006)