The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials

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The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the MMV Malaria Box of candidate antimalarials that could produce syn...

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Bibliographic Details
Main Authors:	Vallieres, Cindy, Avery, Simon V.
Format:	Article
Published:	American Society for Microbiology 2017
Subjects:	Translation fidelity Iron-sulphur cluster Oxidative stress Medicines for malaria 18 venture malaria
Online Access:	https://eprints.nottingham.ac.uk/43724/

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