Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of...
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| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43700/ |
| _version_ | 1848796747146461184 |
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| author | Amer, Mahetab H. Rose, Felicity R.A.J. Shakesheff, Kevin M. Modo, Michel White, Lisa J. |
| author_facet | Amer, Mahetab H. Rose, Felicity R.A.J. Shakesheff, Kevin M. Modo, Michel White, Lisa J. |
| author_sort | Amer, Mahetab H. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell therapy interventions. |
| first_indexed | 2025-11-14T19:52:53Z |
| format | Article |
| id | nottingham-43700 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:52:53Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-437002020-05-04T18:59:49Z https://eprints.nottingham.ac.uk/43700/ Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges Amer, Mahetab H. Rose, Felicity R.A.J. Shakesheff, Kevin M. Modo, Michel White, Lisa J. Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell therapy interventions. Nature Publishing Group 2017-08-10 Article PeerReviewed Amer, Mahetab H., Rose, Felicity R.A.J., Shakesheff, Kevin M., Modo, Michel and White, Lisa J. (2017) Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges. npj Regenerative Medicine, 2 . 23/1-23/13. ISSN 2057-3995 Injectable cell therapy cell delivery cell injection needles syringe viability https://www.nature.com/articles/s41536-017-0028-x doi:10.1038/s41536-017-0028-x doi:10.1038/s41536-017-0028-x |
| spellingShingle | Injectable cell therapy cell delivery cell injection needles syringe viability Amer, Mahetab H. Rose, Felicity R.A.J. Shakesheff, Kevin M. Modo, Michel White, Lisa J. Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title | Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title_full | Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title_fullStr | Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title_full_unstemmed | Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title_short | Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| title_sort | translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges |
| topic | Injectable cell therapy cell delivery cell injection needles syringe viability |
| url | https://eprints.nottingham.ac.uk/43700/ https://eprints.nottingham.ac.uk/43700/ https://eprints.nottingham.ac.uk/43700/ |