Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

QR Code

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intr...

Full description

Bibliographic Details
Main Authors:	Harguindey, Salvador, Stanciu, Daniel, Devesa, Jesús, Alfarouk, Khalid, Cardone, Rosa Angela, Polo Orozco, Julian David, Devesa, Pablo, Rauch, Cyril, Orive, Gorka, Anitua, Eduardo, Roger, Sébastien, Reshkin, Stephan J.
Format:	Article
Published:	Elsevier 2017
Subjects:	Cellular acidification in cancer treatment; Cellular acidifiers; pH NHE cancer and neurodegenerative diseases; Ion channels in cancer and neurodegeneration; Growth factors in cancer and neurodegenerative diseases
Online Access:	https://eprints.nottingham.ac.uk/43674/

Similar Items

Neurogenic potential of human amniotic fluid cells derived from full-term gestation
by: A Hamid, Adila
Published: (2020)

Neurogenic potential of human amniotic fluid cells derived from full-term gestation
by: A Hamid, Adila
Published: (2020)

Neuroregenerative effects of Centella asiatica (L) urban on in vitro and in vivo oxidative stress-induced models of neurodegenerative disease
by: Mansor, Nur 'Izzati
Published: (2021)

Plasma small extracellular vesicles as biomarkers in neurodegenerative dementias: focusing on microglial enrichment in dementia with Lewy bodies
by: Isik, Fatma Busra
Published: (2025)

Targeting Microglia as a Therapeutic Approach to Treat Neuroinflammatory Disorders
by: Almalki, Masi
Published: (2025)

Antitumor Effect of Zerumbone Isolated from Lempoyang (Zingiber Zerumbet) on Human Cervical Cancer Cells and Mouse Cervical Intraepithelial Neoplasia
by: Abdelwahab, Siddig Ibrahim
Published: (2009)

Investigating the role of Cut Like Homeobox 1 CUX1 in colorectal cancer progression
by: Rusnita, Dewi
Published: (2024)

Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes
by: Selvaraju, Thilaga Rati
Published: (2015)

Are supportive services meeting the needs of Australians with neurodegenerative conditions and their tamilies
by: Kristjanson, Linda, et al.
Published: (2006)

Characterisation of Induced Rat Mammary Gland Tumor and the Antitumor Effect of Recombinant Human Erythropoietin and Tamoxifen
by: Abdul Karim, Sairah
Published: (2009)

Molecular and Cytoskeletal Changes in Breast Cancer Cell Lines Treated With Newcastle Disease Virus Strain Af2240
by: Eshak, Zolkapli
Published: (2006)

Cellular Apoptosis of 4T1 Breast Cancer Cells Induced By V4-UPM Newcastle Disease Virus
by: Mahadi, Mahani
Published: (2007)

Construction of a Single Chain Variable Fragment Against Mcf-7 Breast Cancer Cells
by: Ahmad, Zuhaida Asra
Published: (2008)

Morphological and Molecular Characterisation of Ethanolic Neem (Azadirachta Indica) Leaf Extract In an in Vivo Breast Cancer Model
by: Lam, Tsuey Peng
Published: (2007)

Investigating the genetics of sporadic early-onset Alzheimer’s disease using a customised genotyping chip
by: Barber, Imelda Stacey
Published: (2016)

Effects of CXCR4 Silencing by Sirna Engrafted Cotionized Dextran in Mouse Models of Colorectal Cancer and Liver Metastasis
by: Abedini, Fatemeh
Published: (2011)

Investigation of Harmonine inhibition of NMDA receptors
by: Brown Coker, Dennon-jay
Published: (2023)

PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
by: Azmi, Nor Aniza
Published: (2018)

Cancer pharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-fluorouracil / Prof Madya Dr Teh Lay Kek and Prof Dr Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Cultivation, evaluation of the anticancer activities and assessment of the phylogenetic selected strain of Chlorella vulgaris and Spirulina platensis / Mohd Syahril Mohd Zan, Roshani Othman and Nur Hasyimah Ramli
by: Mohd Zan, Mohd Syahril, et al.
Published: (2012)

Cancerpharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-Fluorouracil / Teh Lay Kek And Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Breast cancer knowledge and awareness among non-health sciences university students in Puncak Alam / Noor Syamira Mokhtar, Nurul Ellyna Mohd Noh and Nur Fatin Fatihah Ngah
by: Mokhtar, Noor Syamira, et al.
Published: (2016)

Comparative metabolic changes of tissues and plasma in breast cancer patients / Erda Syerena Rosli
by: Rosli, Erda Syerena
Published: (2015)

Apoptotic mechanism of apigenin and rutin in ER+- breast cancer cells, MCF-7 / Roziana Kamaludin
by: Kamaludin, Roziana
Published: (2015)

Counting the costs of cancer care: breast, cervical and lung cancer in Trent
by: Wolstenholme, Jane
Published: (2001)

Immunomodulatory Effects of Newcastle Disease Virus Strain AF2240 on Human Peripheral Blood Mononuclear Cells Activation and Cytolytic Activity
by: Lam, Han Yuen
Published: (2011)

Engineering recombinant newcastle disease virus with pro-apoptotic gene to enhance oncolysis in selected colorectal cancer cells
by: Kalyanasundram, Jeevanathan
Published: (2020)

Passerini multicomponent reaction: a versatile synthesis of nanomedicines for triple negative breast cancer treatment
by: Travanut, Alessandra
Published: (2021)

Polyadenylation as a target for the treatment of breast cancer
by: Thiyab, Asraa
Published: (2025)

Characterization and anti-cancer effects of citral-loaded nanostructured lipid carrier in breast cancer cells in vitro and in vivo
by: Nordin, Noraini
Published: (2017)

Fabrication, characterization and functionalization of single-walled carbon nanotube conjugated with tamoxifen and its anticancer potential against human breast cancer cells
by: Oskoueian, Arshin
Published: (2018)

In-vitro comparison of anticancer activity between pure gallic acid and gallic acid - iron oxide coated with polyethylene glycol nanoparticles
by: Rosman, Raihana
Published: (2018)

Effects of ampelopsin E towards the invasiveness of triple negative breast cancer cell line, MDA-MB-231
by: Tieng, Francis Yew Fu
Published: (2019)

Effects of silencing dishevelled 1, 2 and 3 mRNA expression on MDA-MB-231 cell migration and invasion using siRNAs
by: Khoo, Samuel Leon Juan
Published: (2015)

Determination of phosphatidylinositol-3-kinase gene copy number and protein expression in nasopharyngeal carcinoma by real-time PCR and immunohistochemistry
by: Firoozinia, Mohammad
Published: (2013)

Formulation and optimization of nanoemulsion containing gemcitabine for lung cancer treatment
by: Wahgiman, Nadiatul Atiqah
Published: (2019)

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research
by: Dichgans, Martin, et al.
Published: (2016)

Synthesis of ganoderic acid analogues to investigate their activity as anti-prostate cancer agents
by: Al-Obaidi, Mohammed
Published: (2019)

Immune Cells Function and Activation in Response to Carica Papaya L. Consumed by Healthy Individuals
by: Loh, Chiew Yee
Published: (2011)

Identification of differentially regulated genes in breast (MCF-7) and lung (H1299) cancer cell lines during Newcastle disease virus strain AF2240 infection
by: Roslan, Nurhidayah
Published: (2012)