Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43674/ |
| _version_ | 1848796740929454080 |
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| author | Harguindey, Salvador Stanciu, Daniel Devesa, Jesús Alfarouk, Khalid Cardone, Rosa Angela Polo Orozco, Julian David Devesa, Pablo Rauch, Cyril Orive, Gorka Anitua, Eduardo Roger, Sébastien Reshkin, Stephan J. |
| author_facet | Harguindey, Salvador Stanciu, Daniel Devesa, Jesús Alfarouk, Khalid Cardone, Rosa Angela Polo Orozco, Julian David Devesa, Pablo Rauch, Cyril Orive, Gorka Anitua, Eduardo Roger, Sébastien Reshkin, Stephan J. |
| author_sort | Harguindey, Salvador |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors. |
| first_indexed | 2025-11-14T19:52:48Z |
| format | Article |
| id | nottingham-43674 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:52:48Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-436742020-05-04T18:43:32Z https://eprints.nottingham.ac.uk/43674/ Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases Harguindey, Salvador Stanciu, Daniel Devesa, Jesús Alfarouk, Khalid Cardone, Rosa Angela Polo Orozco, Julian David Devesa, Pablo Rauch, Cyril Orive, Gorka Anitua, Eduardo Roger, Sébastien Reshkin, Stephan J. During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors. Elsevier 2017-04-30 Article PeerReviewed Harguindey, Salvador, Stanciu, Daniel, Devesa, Jesús, Alfarouk, Khalid, Cardone, Rosa Angela, Polo Orozco, Julian David, Devesa, Pablo, Rauch, Cyril, Orive, Gorka, Anitua, Eduardo, Roger, Sébastien and Reshkin, Stephan J. (2017) Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases. Seminars in Cancer Biology, 43 . pp. 157-179. ISSN 1096-3650 Cellular acidification in cancer treatment; Cellular acidifiers; pH NHE cancer and neurodegenerative diseases; Ion channels in cancer and neurodegeneration; Growth factors in cancer and neurodegenerative diseases http://www.sciencedirect.com/science/article/pii/S1044579X17300196 doi:10.1016/j.semcancer.2017.02.003 doi:10.1016/j.semcancer.2017.02.003 |
| spellingShingle | Cellular acidification in cancer treatment; Cellular acidifiers; pH NHE cancer and neurodegenerative diseases; Ion channels in cancer and neurodegeneration; Growth factors in cancer and neurodegenerative diseases Harguindey, Salvador Stanciu, Daniel Devesa, Jesús Alfarouk, Khalid Cardone, Rosa Angela Polo Orozco, Julian David Devesa, Pablo Rauch, Cyril Orive, Gorka Anitua, Eduardo Roger, Sébastien Reshkin, Stephan J. Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title | Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title_full | Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title_fullStr | Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title_full_unstemmed | Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title_short | Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| title_sort | cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases |
| topic | Cellular acidification in cancer treatment; Cellular acidifiers; pH NHE cancer and neurodegenerative diseases; Ion channels in cancer and neurodegeneration; Growth factors in cancer and neurodegenerative diseases |
| url | https://eprints.nottingham.ac.uk/43674/ https://eprints.nottingham.ac.uk/43674/ https://eprints.nottingham.ac.uk/43674/ |