Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

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Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and ac...

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Bibliographic Details
Main Authors:	Phillips-Jones, Mary K., Channell, Guy Andrew, Kelsall, Claire J., Hughes, Charlotte S., Ashcroft, Alison E., Patching, Simon G., Dinu, Vlad, Gillis, Richard B., Adams, Gary G., Harding, Stephen E.
Format:	Article
Published:	Nature Publishing Group 2017
Online Access:	https://eprints.nottingham.ac.uk/43665/

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