Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies
The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and second-generation antipsychotic drugs. Efforts to...
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| Format: | Article |
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43662/ |
| _version_ | 1848796738663481344 |
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| author | O'Tuathaigh, C.M.P. Moran, P.M. Zhen, X.C. Waddington, J.L. |
| author_facet | O'Tuathaigh, C.M.P. Moran, P.M. Zhen, X.C. Waddington, J.L. |
| author_sort | O'Tuathaigh, C.M.P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and second-generation antipsychotic drugs. Efforts to develop a consensus set of cognitive domains that are both disrupted in schizophrenia and are amenable to cross-species validation (e.g. the NIMH CNTRICS and RDoC initiatives) are an important step towards standardisation of outcome measures that can used in preclinical testing of new drugs. While causative genetic mutations have not been identified, new technologies have identified novel genes as well as hitherto candidate genes previously implicated in the pathophysiology of schizophrenia and/or mechanisms of antipsychotic efficacy. This review comprises a selective summary of these developments, particularly phenotypic data arising from preclinical genetic models for cognitive dysfunction in schizophrenia, with the aim of indicating potential new directions for pro-cognitive therapeutics. |
| first_indexed | 2025-11-14T19:52:45Z |
| format | Article |
| id | nottingham-43662 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:52:45Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-436622020-05-04T18:59:15Z https://eprints.nottingham.ac.uk/43662/ Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies O'Tuathaigh, C.M.P. Moran, P.M. Zhen, X.C. Waddington, J.L. The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and second-generation antipsychotic drugs. Efforts to develop a consensus set of cognitive domains that are both disrupted in schizophrenia and are amenable to cross-species validation (e.g. the NIMH CNTRICS and RDoC initiatives) are an important step towards standardisation of outcome measures that can used in preclinical testing of new drugs. While causative genetic mutations have not been identified, new technologies have identified novel genes as well as hitherto candidate genes previously implicated in the pathophysiology of schizophrenia and/or mechanisms of antipsychotic efficacy. This review comprises a selective summary of these developments, particularly phenotypic data arising from preclinical genetic models for cognitive dysfunction in schizophrenia, with the aim of indicating potential new directions for pro-cognitive therapeutics. Wiley 2017-08-03 Article PeerReviewed O'Tuathaigh, C.M.P., Moran, P.M., Zhen, X.C. and Waddington, J.L. (2017) Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology, 174 (19). pp. 3173-3190. ISSN 1476-5381 http://onlinelibrary.wiley.com/doi/10.1111/bph.13938/abstract doi:10.1111/bph.13938 doi:10.1111/bph.13938 |
| spellingShingle | O'Tuathaigh, C.M.P. Moran, P.M. Zhen, X.C. Waddington, J.L. Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title | Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title_full | Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title_fullStr | Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title_full_unstemmed | Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title_short | Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| title_sort | translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies |
| url | https://eprints.nottingham.ac.uk/43662/ https://eprints.nottingham.ac.uk/43662/ https://eprints.nottingham.ac.uk/43662/ |