3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review
In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Humana Press
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43513/ |
| _version_ | 1848796704930791424 |
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| author | Prina, Elisabetta Mistry, Pritesh Sidney, Laura E. Yang, Jing Wildman, Ricky D. Bertolin, Marina Breda, Claudia Ferrari, Barbara Barbaro, Vanessa Hopkinson, Andrew Dua, Harminder S. Ferrari, Stefano Rose, Felicity R A.J. |
| author_facet | Prina, Elisabetta Mistry, Pritesh Sidney, Laura E. Yang, Jing Wildman, Ricky D. Bertolin, Marina Breda, Claudia Ferrari, Barbara Barbaro, Vanessa Hopkinson, Andrew Dua, Harminder S. Ferrari, Stefano Rose, Felicity R A.J. |
| author_sort | Prina, Elisabetta |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices. |
| first_indexed | 2025-11-14T19:52:13Z |
| format | Article |
| id | nottingham-43513 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:52:13Z |
| publishDate | 2017 |
| publisher | Humana Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-435132020-05-04T18:48:08Z https://eprints.nottingham.ac.uk/43513/ 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review Prina, Elisabetta Mistry, Pritesh Sidney, Laura E. Yang, Jing Wildman, Ricky D. Bertolin, Marina Breda, Claudia Ferrari, Barbara Barbaro, Vanessa Hopkinson, Andrew Dua, Harminder S. Ferrari, Stefano Rose, Felicity R A.J. In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices. Humana Press 2017-06-01 Article PeerReviewed Prina, Elisabetta, Mistry, Pritesh, Sidney, Laura E., Yang, Jing, Wildman, Ricky D., Bertolin, Marina, Breda, Claudia, Ferrari, Barbara, Barbaro, Vanessa, Hopkinson, Andrew, Dua, Harminder S., Ferrari, Stefano and Rose, Felicity R A.J. (2017) 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports . ISSN 1558-6804 Cornea topography microfabrication 3D model microfluidics https://link.springer.com/article/10.1007%2Fs12015-017-9740-6 doi:10.1007/s12015-017-9740-6 doi:10.1007/s12015-017-9740-6 |
| spellingShingle | Cornea topography microfabrication 3D model microfluidics Prina, Elisabetta Mistry, Pritesh Sidney, Laura E. Yang, Jing Wildman, Ricky D. Bertolin, Marina Breda, Claudia Ferrari, Barbara Barbaro, Vanessa Hopkinson, Andrew Dua, Harminder S. Ferrari, Stefano Rose, Felicity R A.J. 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title | 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title_full | 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title_fullStr | 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title_full_unstemmed | 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title_short | 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| title_sort | 3d microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review |
| topic | Cornea topography microfabrication 3D model microfluidics |
| url | https://eprints.nottingham.ac.uk/43513/ https://eprints.nottingham.ac.uk/43513/ https://eprints.nottingham.ac.uk/43513/ |