Investigation of dormancy in acute myeloid leukaemia cells and the induction of dormancy in their response to genotoxic stress

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Investigation of dormancy in acute myeloid leukaemia cells and the induction of dormancy in their response to genotoxic stress

Cancer cells can exist in a reversible state of dormancy (G0 phase of the cell cycle). Relapse of acute myeloid leukaemia (AML) is likely due to dormant cells escape frontline treatment. Dormant AML cells have been identified in the bone marrow (BM) endosteal region which is characterised by an exce...

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Bibliographic Details
Main Author:	Al-Asadi, Mazin Gh.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	Dormant cells Drug resistance in cancer cells Sub-lethal genotoxicity Relapse prevention
Online Access:	https://eprints.nottingham.ac.uk/43320/

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