Using human induced pluripotent stem cells to study the in vitro phenotype of the cardiac channelopathies

QR Code

Using human induced pluripotent stem cells to study the in vitro phenotype of the cardiac channelopathies

Long QT Syndrome 2 (LQTS2) and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) are two prevalent cardiac channelopathies. LQTS2 is the second most common form of LQTS and accounts for up to 45% of cases (Schwartz et al, 2012). CPVT1 is the most common form of CPVT and relates to dysfunc...

Full description

Bibliographic Details
Main Author:	Duncan, Gary
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2017
Subjects:	Human induced pluripotent stem cells LQTS CPVT CRISPR Cardiomyocytes Disease modelling
Online Access:	https://eprints.nottingham.ac.uk/43317/

Similar Items

Evaluating human induced pluripotent stem cell-derived cardiomyocytes for commercial drug testing
by: Katili, Puspita Anggraini
Published: (2020)

Generation of mouse induced pluripotent stem cells using polycistronic lentiviral vector in feeder - and serum-free culture
by: Mahmaud, Akram Faisal
Published: (2015)

Automation and scale-up of human induced pluripotent stem cell models of cardiovascular disease for drug screening
by: Crutchley, James E.B.
Published: (2016)

Current status of drug screening and disease modelling in human pluripotent stem cells
by: Rajamohan, Divya, et al.
Published: (2013)

Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells
by: Kondrashov, Alexander, et al.
Published: (2018)

Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning
by: Lim, Sheng Jye, et al.
Published: (2016)

Human pluripotent stem cells derived-cardiomyocytes (hPSC-CMs) to assess the impact of drug- and gene-induced changes on cell function
by: Mohd Yusof, Nurul Ain Nasim
Published: (2020)

Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies?
by: Kalra, Spandan, et al.
Published: (2016)

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation
by: Dixon, James E., et al.
Published: (2014)

Investigating heparan sulphate in development using human pluripotent stem cells
by: Thompson, Jamie
Published: (2022)

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
by: Sampaziotis, Fotios, et al.
Published: (2017)

Disease modeling hypertrophic cardiomyopathy using CRISPR/Cas9 genome editing technology in human pluripotent stem cell-derived cardiomyocytes
by: Mosqueira, Diogo
Published: (2018)

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy
by: Mosqueira, Diogo, et al.
Published: (2018)

Development of a human induced pluripotent stem cells (hiPSCs)-derived, universal platform, for generation of immunocompetent multi-tissue organoids
by: Azis, Rizal
Published: (2024)

MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo
by: Sala, L., et al.
Published: (2017)

Materials for stem cell factories of the future
by: Celiz, Adam D., et al.
Published: (2014)

In vitro modelling of respiratory infections in idiopathic pulmonary fibrosis (IPF) using human induced pluripotent stem cell (hiPSCs)-derived alveolar epithelial type II cells
by: Serna Valverde, Ana Lilia
Published: (2023)

Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform
by: Denning, Chris, et al.
Published: (2016)

Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation
by: Celiz, Adam D., et al.
Published: (2015)

Developing a chemically defined, xeno-free platform to differentiate human induced pluripotent stem cells to type 2 alveolar epithelial cells of the lung
by: Reed, Liam
Published: (2024)

Gene expression network analysis of the routes to pluripotency
by: Amaral, Fabio M R
Published: (2018)

Linking molecular targets to hypertrophic cardiomyopathy using genome-edited human induced pluripotent stem cell cardiomyocytes
by: Bodbin, S.E.
Published: (2022)

Evaluation of minicircle-induced pluripotent stem cell
by: Daneshvar, Nasibeh
Published: (2014)

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs
by: Bertero, Alessandro, et al.
Published: (2016)

Establishment of the human cardiac models using gene editing and reprogramming in Human Pluripotent Stem Cells to understand the putative functions of the G-protein coupled receptor kinase 5 polymorphism (GRK5-L41)
by: Hoang, Minh Duc
Published: (2017)

Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes
by: Duncan, Gary, et al.
Published: (2017)

A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays
by: Patel, Asha K., et al.
Published: (2015)

Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
by: Lei, Chon-Lok, et al.
Published: (2017)

Generation and Characterisation of Mesenchymal Stem Cells Derived from Placenta and Adult Cardiac Tissue
by: Vellasamy, Shalini
Published: (2011)

Deciphering the role of BMP4 signalling and gene regulation in the specification of human liver progenitor cells
by: Durczak, Paulina Maria
Published: (2023)

Generation and characterization of human cardiac resident and non-resident mesenchymal stem cell
by: Subramani, Baskar, et al.
Published: (2016)

An investigation into the function and mechanism of a GRK5-L41 polymorphism using human pluripotent cell-derived cardiomyocytes
by: Vo, Nguyen T. N.
Published: (2021)

Developing a model system to investigate the epigenetic mechanisms underlying pluripotency in human cells
by: Matsa, Elena
Published: (2010)

Investigating pluripotency and primordial germ cell development in axolotl with a focus on axnanog and axblimp1
by: Redwood, Catherine
Published: (2009)

Engineered human pluripotent stem cell derived cardiomyocyte platforms to detect cardiovascular safety liabilities
by: Firth, Karl
Published: (2017)

Improving the maturation of human pluripotent stem cell - derived hepatocyte-like cells using an automated-design of experiments approach
by: Fotopoulos, Lazaros
Published: (2019)

Generation, propagation and characterization of second and full-term amniotic fluid-derived mesenchymal stem cell
by: Ghoraishizadeh, Peyman
Published: (2016)

Limbal stem cells: The search for a marker
by: Chee, K.Y.H., et al.
Published: (2006)

Exploring the immunomodulatory effects of human mesenchymal stem cells on monocyte functions
by: Maqbool, Maryam
Published: (2016)

Immunomodulatory Effects of Human Mesenchymal Stem Cells on Neutrophil Functions
by: Maqbool, Maryam
Published: (2011)