The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments
Purpose Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths. Methods The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Springer
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43276/ |
| _version_ | 1848796652160155648 |
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| author | Hu, Anran Chen, Chen Mantle, Michael D. Wolf, Bettina Gladden, Lynn F. Rajabi-Siahboomi, Ali Missaghi, Shahrzad Mason, Laura Melia, Colin D. |
| author_facet | Hu, Anran Chen, Chen Mantle, Michael D. Wolf, Bettina Gladden, Lynn F. Rajabi-Siahboomi, Ali Missaghi, Shahrzad Mason, Laura Melia, Colin D. |
| author_sort | Hu, Anran |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Purpose
Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths.
Methods
The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy and magnetic resonance imaging, with respect to polymer ratio and ionic strength of the hydrating media.
Results
Increasing HPMC content gave longer extended release times, but a greater sensitivity to high ionic dissolution environments. Increasing PEO content reduced this sensitivity. The addition of PEO to a predominantly HPMC matrix reduced release rate sensitivity to high ionic environments. Confocal microscopy of early gel layer development showed the two polymers appeared to contribute independently to gel layer structure whilst together forming a coherent and effective diffusion barrier. There was some evidence that poorly swollen HPMC particles added a tortuosity barrier to the gel layer in high ionic strength environments, resulting in prolonged extended release. MRI provides unique, non-invasive spatially resolved information from within the HPMC:PEO compacts that furthers our understanding of USP 1 and USP 4 dissolution data.
Conclusions
Confocal microscopy and MRI data show that combinations of HPMC and PEO have advantageous extended release properties, in comparison with matrices containing a single polymer. |
| first_indexed | 2025-11-14T19:51:23Z |
| format | Article |
| id | nottingham-43276 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:51:23Z |
| publishDate | 2017 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-432762020-05-04T19:57:32Z https://eprints.nottingham.ac.uk/43276/ The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments Hu, Anran Chen, Chen Mantle, Michael D. Wolf, Bettina Gladden, Lynn F. Rajabi-Siahboomi, Ali Missaghi, Shahrzad Mason, Laura Melia, Colin D. Purpose Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths. Methods The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy and magnetic resonance imaging, with respect to polymer ratio and ionic strength of the hydrating media. Results Increasing HPMC content gave longer extended release times, but a greater sensitivity to high ionic dissolution environments. Increasing PEO content reduced this sensitivity. The addition of PEO to a predominantly HPMC matrix reduced release rate sensitivity to high ionic environments. Confocal microscopy of early gel layer development showed the two polymers appeared to contribute independently to gel layer structure whilst together forming a coherent and effective diffusion barrier. There was some evidence that poorly swollen HPMC particles added a tortuosity barrier to the gel layer in high ionic strength environments, resulting in prolonged extended release. MRI provides unique, non-invasive spatially resolved information from within the HPMC:PEO compacts that furthers our understanding of USP 1 and USP 4 dissolution data. Conclusions Confocal microscopy and MRI data show that combinations of HPMC and PEO have advantageous extended release properties, in comparison with matrices containing a single polymer. Springer 2017-05 Article PeerReviewed Hu, Anran, Chen, Chen, Mantle, Michael D., Wolf, Bettina, Gladden, Lynn F., Rajabi-Siahboomi, Ali, Missaghi, Shahrzad, Mason, Laura and Melia, Colin D. (2017) The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments. Pharmaceutical Research, 34 (5). pp. 941-956. ISSN 1573-904X confocal fluorescence microscopy; digital imaging; dissolution; HPMC; hydrophilic matrix; MRI; PEO; polymer mixtures https://link.springer.com/article/10.1007%2Fs11095-016-2031-0 doi:10.1007/s11095-016-2031-0 doi:10.1007/s11095-016-2031-0 |
| spellingShingle | confocal fluorescence microscopy; digital imaging; dissolution; HPMC; hydrophilic matrix; MRI; PEO; polymer mixtures Hu, Anran Chen, Chen Mantle, Michael D. Wolf, Bettina Gladden, Lynn F. Rajabi-Siahboomi, Ali Missaghi, Shahrzad Mason, Laura Melia, Colin D. The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title | The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title_full | The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title_fullStr | The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title_full_unstemmed | The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title_short | The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments |
| title_sort | properties of hpmc: peo extended release hydrophilic matrices and their response to ionic environments |
| topic | confocal fluorescence microscopy; digital imaging; dissolution; HPMC; hydrophilic matrix; MRI; PEO; polymer mixtures |
| url | https://eprints.nottingham.ac.uk/43276/ https://eprints.nottingham.ac.uk/43276/ https://eprints.nottingham.ac.uk/43276/ |