Metal resistance and its association with antibiotic resistance
Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is consi...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Book Section |
| Published: |
Academic Press
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/43240/ |
| _version_ | 1848796643739041792 |
|---|---|
| author | Pal, Chandan Asiani, Karishma R. Arya, Sankalp Rensing, Christopher Stekel, Dov J. Larsson, D.G. Joakim Hobman, Jon L. |
| author2 | Poole, Robert K. |
| author_facet | Poole, Robert K. Pal, Chandan Asiani, Karishma R. Arya, Sankalp Rensing, Christopher Stekel, Dov J. Larsson, D.G. Joakim Hobman, Jon L. |
| author_sort | Pal, Chandan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding. |
| first_indexed | 2025-11-14T19:51:15Z |
| format | Book Section |
| id | nottingham-43240 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:51:15Z |
| publishDate | 2017 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-432402020-05-04T18:46:00Z https://eprints.nottingham.ac.uk/43240/ Metal resistance and its association with antibiotic resistance Pal, Chandan Asiani, Karishma R. Arya, Sankalp Rensing, Christopher Stekel, Dov J. Larsson, D.G. Joakim Hobman, Jon L. Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding. Academic Press Poole, Robert K. 2017-05-18 Book Section PeerReviewed Pal, Chandan, Asiani, Karishma R., Arya, Sankalp, Rensing, Christopher, Stekel, Dov J., Larsson, D.G. Joakim and Hobman, Jon L. (2017) Metal resistance and its association with antibiotic resistance. In: Microbiology of metal ions. Advances in Microbial Physiology, 70 . Academic Press, Oxford, pp. 261-313. ISBN 9780128123867 Antibiotic resistance; Metal ion resistance; Co-selection; Co-resistance; Cross-resistance; Mercury; Copper; Silver; Arsenic; Zinc http://www.sciencedirect.com/science/article/pii/S0065291117300085 doi:10.1016/bs.ampbs.2017.02.001 doi:10.1016/bs.ampbs.2017.02.001 |
| spellingShingle | Antibiotic resistance; Metal ion resistance; Co-selection; Co-resistance; Cross-resistance; Mercury; Copper; Silver; Arsenic; Zinc Pal, Chandan Asiani, Karishma R. Arya, Sankalp Rensing, Christopher Stekel, Dov J. Larsson, D.G. Joakim Hobman, Jon L. Metal resistance and its association with antibiotic resistance |
| title | Metal resistance and its association with antibiotic
resistance |
| title_full | Metal resistance and its association with antibiotic
resistance |
| title_fullStr | Metal resistance and its association with antibiotic
resistance |
| title_full_unstemmed | Metal resistance and its association with antibiotic
resistance |
| title_short | Metal resistance and its association with antibiotic
resistance |
| title_sort | metal resistance and its association with antibiotic
resistance |
| topic | Antibiotic resistance; Metal ion resistance; Co-selection; Co-resistance; Cross-resistance; Mercury; Copper; Silver; Arsenic; Zinc |
| url | https://eprints.nottingham.ac.uk/43240/ https://eprints.nottingham.ac.uk/43240/ https://eprints.nottingham.ac.uk/43240/ |