Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog
A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-def...
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| Format: | Article |
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43226/ |
| _version_ | 1848796640259866624 |
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| author | Polledo, L. Oliveira, M. Adamany, J. Graham, P. Baiker, Kerstin |
| author_facet | Polledo, L. Oliveira, M. Adamany, J. Graham, P. Baiker, Kerstin |
| author_sort | Polledo, L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings. |
| first_indexed | 2025-11-14T19:51:12Z |
| format | Article |
| id | nottingham-43226 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:51:12Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-432262020-05-04T19:06:57Z https://eprints.nottingham.ac.uk/43226/ Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog Polledo, L. Oliveira, M. Adamany, J. Graham, P. Baiker, Kerstin A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings. Wiley 2017-09-14 Article PeerReviewed Polledo, L., Oliveira, M., Adamany, J., Graham, P. and Baiker, Kerstin (2017) Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog. Journal of Veterinary Internal Medicine, 31 (5). pp. 1257-1532. ISSN 1939-1676 MRI; autoimmune; hypoadrenocorticism; diabetes insipidus http://onlinelibrary.wiley.com/doi/10.1111/jvim.14790/full doi:10.1111/jvim.14790 doi:10.1111/jvim.14790 |
| spellingShingle | MRI; autoimmune; hypoadrenocorticism; diabetes insipidus Polledo, L. Oliveira, M. Adamany, J. Graham, P. Baiker, Kerstin Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title | Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title_full | Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title_fullStr | Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title_full_unstemmed | Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title_short | Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog |
| title_sort | hypophysitis, panhypopituitarism, and hypothalamitis in a scottish terrier dog |
| topic | MRI; autoimmune; hypoadrenocorticism; diabetes insipidus |
| url | https://eprints.nottingham.ac.uk/43226/ https://eprints.nottingham.ac.uk/43226/ https://eprints.nottingham.ac.uk/43226/ |