Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers

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Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers

Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO2A, DNA-PKcs, Ku70/Ku80), nucleotide excision repa...

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Bibliographic Details
Main Authors:	Green, Andrew R., Aleskandarany, Mohammed A., Ali, Reem, Hodgson, Eleanor Grace, Atabani, Suha, De Souza, Karen, Ellis, Ian O., Rakha, Emad, Madhusudan, Srinivasan
Format:	Article
Published:	American Association for Cancer Research 2017
Online Access:	https://eprints.nottingham.ac.uk/43070/

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