Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers

QR Code

Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers

RECQL1, a key member of the RecQ family of DNA helicases, is required for DNA replication and DNA repair. Two recent studies have shown that germline RECQL1 mutations are associated with increased breast cancer susceptibility. Whether altered RECQL1 expression has clinicopathologic significance in s...

Full description

Bibliographic Details
Main Authors:	Arora, Arvind, Parvathaneni, Swetha, Aleskandarany, Mohammed A., Agarwal, Devika, Ali, Reem, Abdel-Fatah, Tarek, Green, Andrew R., Ball, Graham R., Rakha, Emad A., Ellis, Ian O., Sharma, Sudha, Madhusudan, Srinivasan
Format:	Article
Published:	American Association for Cancer Research 2017
Online Access:	https://eprints.nottingham.ac.uk/43069/

Similar Items

RECQL4 helicase has oncogenic potential in sporadic breast cancers
by: Arora, Arvind, et al.
Published: (2016)

Transcriptomic and protein expression analysis reveals clinicopathological significance of bloom syndrome helicase (BLM) in breast cancer
by: Arora, Arvind, et al.
Published: (2015)

Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway
by: Mo, Dongliang, et al.
Published: (2016)

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
by: Barone, Giancarlo, et al.
Published: (2018)

Exploring RECQ Helicase landscape in breast cancer
by: Arora, Arvind
Published: (2019)

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner
by: Parvathaneni, Swetha, et al.
Published: (2017)

Targeting ataxia telangiectasia mutated and Rad3 related kinase (ATR) in PTEN deficient breast cancers for personalized therapy
by: Al-Subhi, Nouf, et al.
Published: (2018)

Sporadic cases must be contained
by: Ahmad, Razak, et al.
Published: (2021)

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers
by: Ahmad, Dena Akram Jerjees, et al.
Published: (2016)

Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
by: Green, Andrew R., et al.
Published: (2017)

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
by: van Eijk, Erika, et al.
Published: (2016)

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
by: van Eijk, Erika, et al.
Published: (2016)

Much concern over sporadic cases
by: Tang, Ashley
Published: (2020)

Clinicopathological and prognostic significance of Ras Association and Pleckstrin Homology domains 1 (RAPH1) in breast cancer
by: Kurozumi, Sasagu, et al.
Published: (2018)

Interrogating the genetic profile of sporadic colorectal cancer
by: Fadhil, Wakkas M.
Published: (2019)

Complete genomic landscape of a recurring sporadic parathyroid carcinoma
by: Kasaian, K., et al.
Published: (2013)

Calculating polygenic risk score for individuals with sporadic early onset Alzheimer’s disease
by: Chaudhury, Sultan R
Published: (2017)

Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis
by: Ioannou, Charikleia, et al.
Published: (2006)

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays
by: Tewari, Nilanjana, et al.
Published: (2013)

Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma
by: Sneddon, S., et al.
Published: (2015)

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein
by: Alshareeda, Alaa, et al.
Published: (2016)

Investigations of the DEAD-box helicase eIF4A
by: Phillips, Nicola Marie
Published: (2011)

Biochemical analysis of Hel308 and HelQ helicases
by: Buckley, Ryan J.
Published: (2017)

Genetic and biochemical analysis of the Archaeal Helicase Hel308
by: Simmons, Emily
Published: (2019)

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy
by: Fareed, Khaleel R., et al.
Published: (2012)

Influence of coding variability in APP-Aß metabolism genes in sporadic Alzheimer's disease
by: Sassi, C., et al.
Published: (2016)

Genetic analysis of the Hel308 helicase in the archaeon Haloferax volcanii
by: Gamble-Milner, Rebecca
Published: (2016)

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.
by: Cai, W., et al.
Published: (2017)

Oral cavity non-Hodgkin’s lymphoma: Clinicopathological aspects
by: Shweta N Kalyankar,
Published: (2015)

Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
by: Abd Alabbas, Haider K.
Published: (2012)

A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus
by: Monecke, S., et al.
Published: (2011)

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer’s disease
by: Chaudhary, Sultan, et al.
Published: (2018)

Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis
by: Johnson, L., et al.
Published: (2009)

Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer
by: Tan, Shing Cheng, et al.
Published: (2013)

Molecular spectrum and differential diagnosis in patients referred with sporadic or autosomal recessive osteogenesis imperfecta
by: Caparrós-Martín, Jose, et al.
Published: (2017)

The bacterial helicase-primase interaction: a common structural/functional module
by: Soultanas, Panos
Published: (2005)

Investigating a human DNA repair helicase that supports CRISPR editing
by: Cubbon, Andrew
Published: (2022)

Genetic and biochemical analysis of the Hel308 Helicase in the Archaeon Haloferax volcanii
by: Lever, Rebecca
Published: (2020)

Production Of Uvrd Helicase And Mutl Recombinant Proteins For Helicasedependent Isothermal Amplification
by: Sepuloh Maniam, Sanggetha Periya
Published: (2015)

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?
by: Abdel-Fatah, Tarek, et al.
Published: (2013)