Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release
The principal challenge for the use of boronic acids (BA) as glucose sensors is their lack of specificity for glucose. We examined the selectivity of and insulin release from two boronic acids- (2-formyl-3-thienylboronic acid (FTBA) and 4-formylphenylboronic acid (FPBA)) conjugated chitosan scaffold...
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| Format: | Article |
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Taylor & Francis
2017
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| Online Access: | https://eprints.nottingham.ac.uk/43003/ |
| _version_ | 1848801180455534592 |
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| author | Siddiqui, Nabil A. Billa, Nashiru Roberts, Clive J. |
| author_facet | Siddiqui, Nabil A. Billa, Nashiru Roberts, Clive J. |
| author_sort | Siddiqui, Nabil A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The principal challenge for the use of boronic acids (BA) as glucose sensors is their lack of specificity for glucose. We examined the selectivity of and insulin release from two boronic acids- (2-formyl-3-thienylboronic acid (FTBA) and 4-formylphenylboronic acid (FPBA)) conjugated chitosan scaffolds to glucose and fructose. Adsorption of glucose to BA: chitosan conjugates was dose-dependent up to 1:1 at 35 and 42% for FPBA and FTBA respectively but the FTBA conjugates adsorbed more glucose and fructose at respective FPBA ratios. The affinity of both BA conjugates to glucose decreased with increase in BA ratio. On the other hand, the affinity of both BA conjugates for fructose decreased from ratio 1:1 to 2:1 then rose again at 3:1. Insulin release from FPBA nanoparticles (FPBAINP) and FTBA nanoparticles (FTBAINP) were both concentration-dependent within glyceamically relevant values (1–3 mg/ml glucose and 0.002 mg/ml fructose). Furthermore, the total amounts of insulin released from FPBAINP in both the media were higher than from FTBAINP. Both FPBAINP and FTBAINP have the potential for development as a glucose-selective insulin delivery system in physiological settings. |
| first_indexed | 2025-11-14T19:50:53Z |
| format | Article |
| id | nottingham-43003 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T21:03:21Z |
| publishDate | 2017 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-430032025-09-09T13:39:57Z https://eprints.nottingham.ac.uk/43003/ Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release Siddiqui, Nabil A. Billa, Nashiru Roberts, Clive J. The principal challenge for the use of boronic acids (BA) as glucose sensors is their lack of specificity for glucose. We examined the selectivity of and insulin release from two boronic acids- (2-formyl-3-thienylboronic acid (FTBA) and 4-formylphenylboronic acid (FPBA)) conjugated chitosan scaffolds to glucose and fructose. Adsorption of glucose to BA: chitosan conjugates was dose-dependent up to 1:1 at 35 and 42% for FPBA and FTBA respectively but the FTBA conjugates adsorbed more glucose and fructose at respective FPBA ratios. The affinity of both BA conjugates to glucose decreased with increase in BA ratio. On the other hand, the affinity of both BA conjugates for fructose decreased from ratio 1:1 to 2:1 then rose again at 3:1. Insulin release from FPBA nanoparticles (FPBAINP) and FTBA nanoparticles (FTBAINP) were both concentration-dependent within glyceamically relevant values (1–3 mg/ml glucose and 0.002 mg/ml fructose). Furthermore, the total amounts of insulin released from FPBAINP in both the media were higher than from FTBAINP. Both FPBAINP and FTBAINP have the potential for development as a glucose-selective insulin delivery system in physiological settings. Taylor & Francis 2017-03-09 Article PeerReviewed Siddiqui, Nabil A., Billa, Nashiru and Roberts, Clive J. (2017) Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release. Journal of Biomaterials Science, Polymer Edition, 28 (8). pp. 781-793. ISSN 1568-5624 Boronic acid chitosan glucose insulin nanoparticles http://www.tandfonline.com/doi/full/10.1080/09205063.2017.1301774 doi:10.1080/09205063.2017.1301774 doi:10.1080/09205063.2017.1301774 |
| spellingShingle | Boronic acid chitosan glucose insulin nanoparticles Siddiqui, Nabil A. Billa, Nashiru Roberts, Clive J. Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title | Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title_full | Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title_fullStr | Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title_full_unstemmed | Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title_short | Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| title_sort | multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release |
| topic | Boronic acid chitosan glucose insulin nanoparticles |
| url | https://eprints.nottingham.ac.uk/43003/ https://eprints.nottingham.ac.uk/43003/ https://eprints.nottingham.ac.uk/43003/ |