Computer models to simulate ion flow in neurons
In this thesis the Drift Diffusion enhanced Hodgkin Huxley model is developed. This model uses the Drift Diffusion equations to model the bulk solutions both within a neuron and in the surrounding extracellular media. The Hodgkin Huxley ion channel behaviour is incorporated into the membrane region...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2017
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| Online Access: | https://eprints.nottingham.ac.uk/42951/ |
| _version_ | 1848796609302757376 |
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| author | Clay, Robert Christopher |
| author_facet | Clay, Robert Christopher |
| author_sort | Clay, Robert Christopher |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In this thesis the Drift Diffusion enhanced Hodgkin Huxley model is developed. This model uses the Drift Diffusion equations to model the bulk solutions both within a neuron and in the surrounding extracellular media. The Hodgkin Huxley ion channel behaviour is incorporated into the membrane regions through the use of an altered diffusion coefficient.
Firstly the model is applied to the case of intracellular and extracellular media separated by a single membrane.
Secondly the model is applied to a cell within a restricted extracellular space. This takes a slice through a cell and is therefore termed a double membrane model, since there are two membrane layers.
Finally the model is used to determine whether there is any charge and field buildup on a gold surface located 100 nm from the cell. The results from this could then be used in future to model Surface Plasmon Resonance experiments which may form the basis of novel neuronal activity detectors. |
| first_indexed | 2025-11-14T19:50:42Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-42951 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T19:50:42Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-429512025-02-28T13:46:40Z https://eprints.nottingham.ac.uk/42951/ Computer models to simulate ion flow in neurons Clay, Robert Christopher In this thesis the Drift Diffusion enhanced Hodgkin Huxley model is developed. This model uses the Drift Diffusion equations to model the bulk solutions both within a neuron and in the surrounding extracellular media. The Hodgkin Huxley ion channel behaviour is incorporated into the membrane regions through the use of an altered diffusion coefficient. Firstly the model is applied to the case of intracellular and extracellular media separated by a single membrane. Secondly the model is applied to a cell within a restricted extracellular space. This takes a slice through a cell and is therefore termed a double membrane model, since there are two membrane layers. Finally the model is used to determine whether there is any charge and field buildup on a gold surface located 100 nm from the cell. The results from this could then be used in future to model Surface Plasmon Resonance experiments which may form the basis of novel neuronal activity detectors. 2017-07-12 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/42951/1/Computer%20Models%20to%20Simulate%20Ion%20Flow%20in%20Neurons.pdf Clay, Robert Christopher (2017) Computer models to simulate ion flow in neurons. PhD thesis, University of Nottingham. Drift Diffusion Hodgkin Huxley Neurons |
| spellingShingle | Drift Diffusion Hodgkin Huxley Neurons Clay, Robert Christopher Computer models to simulate ion flow in neurons |
| title | Computer models to simulate ion flow in neurons |
| title_full | Computer models to simulate ion flow in neurons |
| title_fullStr | Computer models to simulate ion flow in neurons |
| title_full_unstemmed | Computer models to simulate ion flow in neurons |
| title_short | Computer models to simulate ion flow in neurons |
| title_sort | computer models to simulate ion flow in neurons |
| topic | Drift Diffusion Hodgkin Huxley Neurons |
| url | https://eprints.nottingham.ac.uk/42951/ |