Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents

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Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents

A novel class of NO-donating protoberberine derivatives were synthesized and initially evaluated for their anti-hepatocellular carcinoma activities. Most of the compounds exhibited more potent activity against HepG2 cells than parent compounds berberine and palmatine. In particular, compound 15a exe...

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Bibliographic Details
Main Authors:	Chen, Jichao, Wang, Tianyu, Xu, Shengtao, Lin, Aijun, Yao, Hequan, Xie, Weijia, Zhu, Zheying, Xu, Jinyi
Format:	Article
Published:	Elsevier 2017
Subjects:	Berberine; Palmatine; Nitric oxide (NO) donor; Hybrid compound; Antitumor activity
Online Access:	https://eprints.nottingham.ac.uk/42904/

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