Design, synthesis, and biological evaluation of NAD(P)H: quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation

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Design, synthesis, and biological evaluation of NAD(P)H: quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation

The enzyme NQO1 is a potential target for selective cancer therapy due to its overexpression in certain hypoxic tumors. A series of prodrugs possessing a variety of cytotoxic diterpenoids (oridonin and its analogues) as the leaving groups activated by NQO1 were synthesized by functionalization of 3-...

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Bibliographic Details
Main Authors:	Xu, Shengtao, Yao, Hong, Pei, Lingling, Hu, Mei, Li, Dahong, Qiu, Yangyi, Wang, Guangyu, Wu, Liang, Yao, Hequan, Zhu, Zheying, Xu, Jinyi
Format:	Article
Published:	Elsevier 2017
Subjects:	NQO1 Oridonin Indolequinone Hypoxia-selective Antitumor
Online Access:	https://eprints.nottingham.ac.uk/42902/

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