Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis
A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidan...
| Main Authors: | Chen, Jichao, Wang, Ruifan, Wang, Tianyu, Ding, Qilong, Khalil, Aliahmad, Xu, Shengtao, Lin, Aijun, Yao, Hequan, Xie, Weijia, Zhu, Zheying, Xu, Jinyi |
|---|---|
| Format: | Article |
| Published: |
American Chemical Society
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/42901/ |
Similar Items
Novel hybrids of natural β-elemene bearing isopropanolamine
moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
by: Chen, Jichao, et al.
Published: (2017)
by: Chen, Jichao, et al.
Published: (2017)
Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway
by: Chen, Jichao, et al.
Published: (2017)
by: Chen, Jichao, et al.
Published: (2017)
Fabrication, characterization and evaluation of β-elemene nanoparticles for anti-cancer treatment
by: Zhao, Xi
Published: (2020)
by: Zhao, Xi
Published: (2020)
Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents
by: Chen, Jichao, et al.
Published: (2017)
by: Chen, Jichao, et al.
Published: (2017)
Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target
by: Apps, John R., et al.
Published: (2018)
by: Apps, John R., et al.
Published: (2018)
Synthesis and mesomorphic properties of non-symmetric liquid crystalline dimers containing azobenzene groups
by: Rahman, Md Lutfor, et al.
Published: (2009)
by: Rahman, Md Lutfor, et al.
Published: (2009)
Synthesis and characterization of two series of non-symmetric liquid crystal dimer containing bisazobenzene moiety
by: Salisu, Abdulsalam Abubakar, et al.
Published: (2009)
by: Salisu, Abdulsalam Abubakar, et al.
Published: (2009)
Unphosphorylated dimers are not required for the assembly of
active STAT1 and STAT3 homo-and heterodimers
by: Krause, Sebastian C.
Published: (2023)
by: Krause, Sebastian C.
Published: (2023)
Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers
by: Ahmad, Dena Akram Jerjees, et al.
Published: (2016)
by: Ahmad, Dena Akram Jerjees, et al.
Published: (2016)
Dynamical fluctuations of classical and quantum square dimer models
by: Oakes, Tom
Published: (2019)
by: Oakes, Tom
Published: (2019)
Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
by: Hill, Stephen J., et al.
Published: (2014)
by: Hill, Stephen J., et al.
Published: (2014)
Synchronization transition in the double dimer model
by: Wilkins, Neil
Published: (2021)
by: Wilkins, Neil
Published: (2021)
Identifying and targeting dormant cells in acute myeloid leukaemia
by: Yu, N.
Published: (2016)
by: Yu, N.
Published: (2016)
FLYWCH1, a novel transcription regulator with potential tumour suppressor activity
by: Almozyan, Sheema
Published: (2021)
by: Almozyan, Sheema
Published: (2021)
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
by: Sethi, G., et al.
Published: (2014)
by: Sethi, G., et al.
Published: (2014)
Topics in the mathematical modelling of nanotoxicology
by: Jones, Zofia
Published: (2012)
by: Jones, Zofia
Published: (2012)
The molecular basis of Gs protein efficacy at the b2- adrenoceptor
by: Harwood, Clare
Published: (2022)
by: Harwood, Clare
Published: (2022)
Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation
by: Gherbi, Karolina, et al.
Published: (2015)
by: Gherbi, Karolina, et al.
Published: (2015)
6,7-seco-ent-kauranoids derived from oridonin as potential
anticancer agents
by: Xu, Shengtao, et al.
Published: (2017)
by: Xu, Shengtao, et al.
Published: (2017)
Development of methods for cell apoptosis
by: Chen, S., et al.
Published: (2003)
by: Chen, S., et al.
Published: (2003)
Mechanisms of Nordamnacanthal-Induced Apoptosis in Breast Cancer Cell Lines (MCF-7) and Acute T-Lymphoblastic Leukimia (MOLT-4)
by: Ishak, Norsyafini
Published: (2011)
by: Ishak, Norsyafini
Published: (2011)
Investigations into β2-adrenoceptor pharmacology: kinetic analysis, mechanotransduction and allosteric modulation
by: Cullum, Sean A.
Published: (2024)
by: Cullum, Sean A.
Published: (2024)
The structural modification of natural products for
novel drug discovery
by: Yao, Hong, et al.
Published: (2016)
by: Yao, Hong, et al.
Published: (2016)
Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
by: Li, Wenlong, et al.
Published: (2017)
by: Li, Wenlong, et al.
Published: (2017)
Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
by: Wilkinson, Daniel J., et al.
Published: (2017)
by: Wilkinson, Daniel J., et al.
Published: (2017)
Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents
by: Adams, James, et al.
Published: (2014)
by: Adams, James, et al.
Published: (2014)
Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK
by: Liu, Qing-Mei, et al.
Published: (2016)
by: Liu, Qing-Mei, et al.
Published: (2016)
Induction of apoptosis in A549 cells in vitro by Boesenbergin A isolated from Boesenbergia rotunda
by: Mohd Isa, Norbaiti
Published: (2013)
by: Mohd Isa, Norbaiti
Published: (2013)
Effect of encapsulation of D-limonene on the moisture adsorption property of ß-cyclodextrin
by: Fang, Zhongxiang, et al.
Published: (2013)
by: Fang, Zhongxiang, et al.
Published: (2013)
Characterization and cytotoxicity of clausenidin from Clausena excavata Burm f. and its effects on cell cycle regulation and apoptosis of liver (hepg2) and colon (ht29) cancer cell lines
by: Waziri, Peter Maitalata
Published: (2017)
by: Waziri, Peter Maitalata
Published: (2017)
Adsorption kinetics and thermodynamics of water-insoluble crosslinked β-cyclodextrin polymer for phenol in aqueous solution
by: Huang, Hui, et al.
Published: (2013)
by: Huang, Hui, et al.
Published: (2013)
Effect of Bcl-2 overexpression on cell cycle and antibody productivity in chemostat cultures of myeloma NS0 cells
by: Tey, Beng Ti, et al.
Published: (2005)
by: Tey, Beng Ti, et al.
Published: (2005)
Fabrication of β-cyclodextrin modified mesostructured silica coated multi-walled carbon nanotubes composites and application for paraben removal
by: Ding, Chuyuan, et al.
Published: (2018)
by: Ding, Chuyuan, et al.
Published: (2018)
Design, synthesis, and biological evaluation of NAD(P)H: quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation
by: Xu, Shengtao, et al.
Published: (2017)
by: Xu, Shengtao, et al.
Published: (2017)
Apoptotic cell death via oxidative stress mediated caspase-dependent mechanism in Jurkat T cells by cardamonin and its transition metal Cu (II) and Fe (II) complexes
by: Khoo, Yi Vonn
Published: (2018)
by: Khoo, Yi Vonn
Published: (2018)
Transcriptome and apoptosis analysis of feline infectious peritonitis virus-infected crandell rees feline kidney cells
by: Harun, Mohammad Syamsul Reza
Published: (2012)
by: Harun, Mohammad Syamsul Reza
Published: (2012)
Induction of apoptosis by cis-3-(3',4'-dimethoxyphenyl)-4-[(E)-3"',4"'-dimethoxystyryl]cyclohex-1-ene isolated from the rhizome of Zingiber cassumunar roxb. on human T-lymphoblastic leukemia cell line, CEMss
by: Anasamy, Theebaa
Published: (2013)
by: Anasamy, Theebaa
Published: (2013)
Establishment of a cho cell line by over-expression of the X-linked inhibitor of apoptosis
by: Liew, Jane Chiar Jenn
Published: (2012)
by: Liew, Jane Chiar Jenn
Published: (2012)
Zerumbone and small interference RNA induced apoptosis in MCF-7 cell and mammary gland tumor via β-catenin protein inhibition
by: Fadl, Safa Abd Elfatah Amin
Published: (2013)
by: Fadl, Safa Abd Elfatah Amin
Published: (2013)
Induction of apoptosis by Elephantopus scaber L. ethanolic extract and effects of its interaction with tamoxifen on human breast cancer MCF-7 spheroids
by: Ho, Wan Yong
Published: (2012)
by: Ho, Wan Yong
Published: (2012)
Similar Items
-
Novel hybrids of natural β-elemene bearing isopropanolamine
moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
by: Chen, Jichao, et al.
Published: (2017) -
Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway
by: Chen, Jichao, et al.
Published: (2017) -
Fabrication, characterization and evaluation of β-elemene nanoparticles for anti-cancer treatment
by: Zhao, Xi
Published: (2020) -
Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents
by: Chen, Jichao, et al.
Published: (2017) -
Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target
by: Apps, John R., et al.
Published: (2018)