Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis
A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidan...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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American Chemical Society
2017
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| Online Access: | https://eprints.nottingham.ac.uk/42901/ |
| _version_ | 1848796597146615808 |
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| author | Chen, Jichao Wang, Ruifan Wang, Tianyu Ding, Qilong Khalil, Aliahmad Xu, Shengtao Lin, Aijun Yao, Hequan Xie, Weijia Zhu, Zheying Xu, Jinyi |
| author_facet | Chen, Jichao Wang, Ruifan Wang, Tianyu Ding, Qilong Khalil, Aliahmad Xu, Shengtao Lin, Aijun Yao, Hequan Xie, Weijia Zhu, Zheying Xu, Jinyi |
| author_sort | Chen, Jichao |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner. Further studies suggested that the cytoprotective action of D5 might be mediated, at least in part, by increasing the intracellular superoxide dismutase activity and nitric oxide secretion as well as decreasing the intracellular malonyldialdehyde content and lactate dehydrogenase release. Furthermore, D5 observably inhibited ROS generation and prevented H2O2-induced apoptosis in HUVECs possibly via inhibiting the activation of the MAPK signaling pathway. |
| first_indexed | 2025-11-14T19:50:30Z |
| format | Article |
| id | nottingham-42901 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:30Z |
| publishDate | 2017 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-429012020-05-04T18:37:25Z https://eprints.nottingham.ac.uk/42901/ Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis Chen, Jichao Wang, Ruifan Wang, Tianyu Ding, Qilong Khalil, Aliahmad Xu, Shengtao Lin, Aijun Yao, Hequan Xie, Weijia Zhu, Zheying Xu, Jinyi A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner. Further studies suggested that the cytoprotective action of D5 might be mediated, at least in part, by increasing the intracellular superoxide dismutase activity and nitric oxide secretion as well as decreasing the intracellular malonyldialdehyde content and lactate dehydrogenase release. Furthermore, D5 observably inhibited ROS generation and prevented H2O2-induced apoptosis in HUVECs possibly via inhibiting the activation of the MAPK signaling pathway. American Chemical Society 2017-03-13 Article PeerReviewed Chen, Jichao, Wang, Ruifan, Wang, Tianyu, Ding, Qilong, Khalil, Aliahmad, Xu, Shengtao, Lin, Aijun, Yao, Hequan, Xie, Weijia, Zhu, Zheying and Xu, Jinyi (2017) Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis. ACS Medicinal Chemistry Letters, 8 (4). pp. 443-448. ISSN 1948-5875 antioxidant activity; apoptosis; dimer; MAPK pathway; β-Elemene http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.7b00035 doi:10.1021/acsmedchemlett.7b00035 doi:10.1021/acsmedchemlett.7b00035 |
| spellingShingle | antioxidant activity; apoptosis; dimer; MAPK pathway; β-Elemene Chen, Jichao Wang, Ruifan Wang, Tianyu Ding, Qilong Khalil, Aliahmad Xu, Shengtao Lin, Aijun Yao, Hequan Xie, Weijia Zhu, Zheying Xu, Jinyi Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title | Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title_full | Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title_fullStr | Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title_full_unstemmed | Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title_short | Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis |
| title_sort | antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting h2o2‑induced apoptosis |
| topic | antioxidant activity; apoptosis; dimer; MAPK pathway; β-Elemene |
| url | https://eprints.nottingham.ac.uk/42901/ https://eprints.nottingham.ac.uk/42901/ https://eprints.nottingham.ac.uk/42901/ |