Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway

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Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway

A series of novel furoxan-based NO-donating b-elemene hybrids were designed and synthesized to improve the anticancer efficacy of natural b-elemene. The bioassay results indicated that all of the target compounds exhibited significantly improved antiproliferative activities against three cancer cell...

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Bibliographic Details
Main Authors:	Chen, Jichao, Wang, Tianyu, Xu, Shengtao, Zhang, Pengfei, Lin, Aijun, Wu, Liang, Yao, Hequan, Xie, Weijia, Zhu, Zheying, Xu, Jinyi
Format:	Article
Published:	Elsevier 2017
Subjects:	β-Elemene; Furoxan; Antitumor activity; Apoptosis; PI3K/Akt pathway
Online Access:	https://eprints.nottingham.ac.uk/42899/

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