Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics
The maximum plasma concentration (Cmax) and the area under the plasma concentration–time curve (AUC) are commonly used to establish bioequivalence between two formulations of the same oral medication. Similarly, these pharmacokinetic parameters have also been used to establish bioequivalence between...
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| Format: | Article |
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Springer
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42880/ |
| _version_ | 1848796591760080896 |
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| author | Lee, Lik Hang N. Choi, Charles Gershkovich, Pavel Barr, Alasdair M. Honer, William G. Procyshyn, Ric M. |
| author_facet | Lee, Lik Hang N. Choi, Charles Gershkovich, Pavel Barr, Alasdair M. Honer, William G. Procyshyn, Ric M. |
| author_sort | Lee, Lik Hang N. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The maximum plasma concentration (Cmax) and the area under the plasma concentration–time curve (AUC) are commonly used to establish bioequivalence between two formulations of the same oral medication. Similarly, these pharmacokinetic parameters have also been used to establish bioequivalence between two sites of administration for the same injectable formulation. However, these conventional methods of establishing bioequivalence are of limited use when comparing modified-release formulations of a drug, particularly those with rates of absorption that are amenable to change with the site of injection. Inherent differences in the rate of absorption can result in clinically significant differences in early exposure and drug response. Here, we propose the use of the partial AUC (pAUC) as a measure of early exposure to aid in the assessment of bioequivalence between the gluteal and the deltoid site of administration for long-acting injectable antipsychotics. |
| first_indexed | 2025-11-14T19:50:25Z |
| format | Article |
| id | nottingham-42880 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:25Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428802020-05-04T19:59:46Z https://eprints.nottingham.ac.uk/42880/ Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics Lee, Lik Hang N. Choi, Charles Gershkovich, Pavel Barr, Alasdair M. Honer, William G. Procyshyn, Ric M. The maximum plasma concentration (Cmax) and the area under the plasma concentration–time curve (AUC) are commonly used to establish bioequivalence between two formulations of the same oral medication. Similarly, these pharmacokinetic parameters have also been used to establish bioequivalence between two sites of administration for the same injectable formulation. However, these conventional methods of establishing bioequivalence are of limited use when comparing modified-release formulations of a drug, particularly those with rates of absorption that are amenable to change with the site of injection. Inherent differences in the rate of absorption can result in clinically significant differences in early exposure and drug response. Here, we propose the use of the partial AUC (pAUC) as a measure of early exposure to aid in the assessment of bioequivalence between the gluteal and the deltoid site of administration for long-acting injectable antipsychotics. Springer 2016-12 Article PeerReviewed Lee, Lik Hang N., Choi, Charles, Gershkovich, Pavel, Barr, Alasdair M., Honer, William G. and Procyshyn, Ric M. (2016) Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics. European Journal of Drug Metabolism and Pharmacokinetics, 41 (6). pp. 659-664. ISSN 2107-0180 http://link.springer.com/article/10.1007%2Fs13318-016-0348-z doi:10.1007/s13318-016-0348-z doi:10.1007/s13318-016-0348-z |
| spellingShingle | Lee, Lik Hang N. Choi, Charles Gershkovich, Pavel Barr, Alasdair M. Honer, William G. Procyshyn, Ric M. Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title | Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title_full | Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title_fullStr | Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title_full_unstemmed | Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title_short | Proposing the use of partial AUC as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| title_sort | proposing the use of partial auc as an adjunctive measure in establishing bioequivalence between deltoid and gluteal administration of long-acting injectable antipsychotics |
| url | https://eprints.nottingham.ac.uk/42880/ https://eprints.nottingham.ac.uk/42880/ https://eprints.nottingham.ac.uk/42880/ |