An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression

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An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression

The expression of epidermal growth factor receptor (EGFR/ERBB1/HER1) is implicated in the progress of numerous cancers, a feature that has been exploited in the development of EGFR antibodies and EGFR tyrosine kinase inhibitors as anti-cancer drugs. However, EGFR also has important normal cellular f...

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Bibliographic Details
Main Authors:	Webb, Thomas E., Hughes, A., Smalley, D.S., Spriggs, Keith
Format:	Article
Published:	Nature Publishing Group 2015
Online Access:	https://eprints.nottingham.ac.uk/42877/

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